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Inhibition of the AKT1/mTOR pathway through SIRT6 over expression downregulated the expression of programmed death-ligand 1 and prolonged overall survival in lung adenocarcinoma

BACKGROUND: Programmed death-ligand 1 (PD-L1) is a common biomarker of immune checkpoint inhibitors (ICIs). The purpose of our study was to investigate the relationship between Sirtuin 6 (SIRT6) and PD-L1 expressions in lung adenocarcinoma. METHODS: Recombinant plasmids containing green fluorescent...

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Detalles Bibliográficos
Autores principales:	Yuan, Zi-Fu, Lin, Yi-Dong, Wu, Gui-Shu, Li, Lin, Yang, Jing-Pin, Zhang, Jian-Wen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9906195/ https://www.ncbi.nlm.nih.gov/pubmed/36760260 http://dx.doi.org/10.21037/atm-22-6218

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