A mechanistic study on the cellular uptake, intracellular trafficking, and antisense gene regulation of bottlebrush polymer-conjugated oligonucleotides

We have developed a non-cationic transfection vector in the form of bottlebrush polymer-antisense oligonucleotide (ASO) conjugates. Termed pacDNA (polymer-assisted compaction of DNA), these agents show improved biopharmaceutical characteristics and antisense potency in vivo while suppressing non-ant...

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Detalles Bibliográficos
Autores principales: Zhang, Lei, Wang, Yuyan, Chen, Peiru, Wang, Dali, Sun, Tingyu, Zhang, Zheyu, Wang, Ruimeng, Kang, Xi, Fang, Yang, Lu, Hao, Cai, Jiansong, Ren, Mengqi, Dong, Sijia S., Zhang, Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9906284/
https://www.ncbi.nlm.nih.gov/pubmed/36794022
http://dx.doi.org/10.1039/d2cb00149g

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