Macrophages inhibit Coxiella burnetii by the ACOD1‐itaconate pathway for containment of Q fever

Infection with the intracellular bacterium Coxiella (C.) burnetii can cause chronic Q fever with severe complications and limited treatment options. Here, we identify the enzyme cis‐aconitate decarboxylase 1 (ACOD1 or IRG1) and its product itaconate as protective host immune pathway in Q fever. Infe...

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Detalles Bibliográficos
Autores principales: Kohl, Lisa, Siddique, Md Nur A Alam, Bodendorfer, Barbara, Berger, Raffaela, Preikschat, Annica, Daniel, Christoph, Ölke, Martha, Liebler‐Tenorio, Elisabeth, Schulze‐Luehrmann, Jan, Mauermeir, Michael, Yang, Kai‐Ting, Hayek, Inaya, Szperlinski, Manuela, Andrack, Jennifer, Schleicher, Ulrike, Bozec, Aline, Krönke, Gerhard, Murray, Peter J, Wirtz, Stefan, Yamamoto, Masahiro, Schatz, Valentin, Jantsch, Jonathan, Oefner, Peter, Degrandi, Daniel, Pfeffer, Klaus, Mertens‐Scholz, Katja, Rauber, Simon, Bogdan, Christian, Dettmer, Katja, Lührmann, Anja, Lang, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9906395/
https://www.ncbi.nlm.nih.gov/pubmed/36479617
http://dx.doi.org/10.15252/emmm.202215931

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