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Tuned activation of MSLN-CAR T cells induces superior antitumor responses in ovarian cancer models

BACKGROUND: Limited persistence of functional CAR T cells in the immunosuppressive solid tumor microenvironment remains a major hurdle in the successful translation of CAR T cell therapy to treat solid tumors. Fine-tuning of CAR T cell activation by mutating CD3ζ chain immunoreceptor tyrosine-based...

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Detalles Bibliográficos
Autores principales:	Schoutrop, Esther, Poiret, Thomas, El-Serafi, Ibrahim, Zhao, Ying, He, Rui, Moter, Alina, Henriksson, Johan, Hassan, Moustapha, Magalhaes, Isabelle, Mattsson, Jonas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2023
Materias:	Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9906404/ https://www.ncbi.nlm.nih.gov/pubmed/36746513 http://dx.doi.org/10.1136/jitc-2022-005691

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