LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease

Mitochondria comprise the central metabolic hub of cells and their imbalance plays a pathogenic role in chronic kidney disease (CKD). Here, we studied Lon protease 1 (LONP1), a major mitochondrial protease, as its role in CKD pathogenesis is unclear. LONP1 expression was decreased in human patients...

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Detalles Bibliográficos
Autores principales: Bai, Mi, Wu, Mengqiu, Jiang, Mingzhu, He, Jia, Deng, Xu, Xu, Shuang, Fan, Jiaojiao, Miao, Mengqiu, Wang, Ting, Li, Yuting, Yu, Xiaowen, Wang, Lin, Zhang, Yue, Huang, Songming, Yang, Li, Jia, Zhanjun, Zhang, Aihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9906428/
https://www.ncbi.nlm.nih.gov/pubmed/36629048
http://dx.doi.org/10.15252/emmm.202216581

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