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Coupling of α-bromoamides and unactivated alkenes to form γ-lactams through EDA and photocatalysis
γ-Lactams are prevalent in small-molecule pharmaceuticals and provide useful precursors to highly substituted pyrrolidines. Despite numerous methods for the synthesis of this valuable motif, previous redox approaches to γ-lactam synthesis from α-haloamides and olefins require additional electron wit...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9906710/ https://www.ncbi.nlm.nih.gov/pubmed/36794189 http://dx.doi.org/10.1039/d2sc05973h |