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A biodegradable covalent organic framework for synergistic tumor therapy

Stimulus-responsive biodegradable nanocarriers with tumor-selective targeted drug delivery are critical for cancer therapy. Herein, we report for the first time a redox-responsive disulfide-linked porphyrin covalent organic framework (COF) that can be nanocrystallized by glutathione (GSH)-triggered...

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Autores principales: Li, Wen-Yan, Wan, Jing-Jing, Kan, Jing-Lan, Wang, Bo, Song, Tian, Guan, Qun, Zhou, Le-Le, Li, Yan-An, Dong, Yu-Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9906711/
https://www.ncbi.nlm.nih.gov/pubmed/36794183
http://dx.doi.org/10.1039/d2sc05732h
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author Li, Wen-Yan
Wan, Jing-Jing
Kan, Jing-Lan
Wang, Bo
Song, Tian
Guan, Qun
Zhou, Le-Le
Li, Yan-An
Dong, Yu-Bin
author_facet Li, Wen-Yan
Wan, Jing-Jing
Kan, Jing-Lan
Wang, Bo
Song, Tian
Guan, Qun
Zhou, Le-Le
Li, Yan-An
Dong, Yu-Bin
author_sort Li, Wen-Yan
collection PubMed
description Stimulus-responsive biodegradable nanocarriers with tumor-selective targeted drug delivery are critical for cancer therapy. Herein, we report for the first time a redox-responsive disulfide-linked porphyrin covalent organic framework (COF) that can be nanocrystallized by glutathione (GSH)-triggered biodegradation. After loading 5-fluorouracil (5-Fu), the generated nanoscale COF-based multifunctional nanoagent can be further effectively dissociated by endogenous GSH in tumor cells, releasing 5-Fu efficiently to achieve selective chemotherapy on tumor cells. Together with the GSH depletion-enhanced photodynamic therapy (PDT), an ideal synergistic tumor therapy for MCF-7 breast cancer via ferroptosis is achieved. In this research, the therapeutic efficacy was significantly improved in terms of enhanced combined anti-tumor efficiency and reduced side effects by responding to significant abnormalities such as high concentrations of GSH in the tumor microenvironment (TME).
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spelling pubmed-99067112023-02-14 A biodegradable covalent organic framework for synergistic tumor therapy Li, Wen-Yan Wan, Jing-Jing Kan, Jing-Lan Wang, Bo Song, Tian Guan, Qun Zhou, Le-Le Li, Yan-An Dong, Yu-Bin Chem Sci Chemistry Stimulus-responsive biodegradable nanocarriers with tumor-selective targeted drug delivery are critical for cancer therapy. Herein, we report for the first time a redox-responsive disulfide-linked porphyrin covalent organic framework (COF) that can be nanocrystallized by glutathione (GSH)-triggered biodegradation. After loading 5-fluorouracil (5-Fu), the generated nanoscale COF-based multifunctional nanoagent can be further effectively dissociated by endogenous GSH in tumor cells, releasing 5-Fu efficiently to achieve selective chemotherapy on tumor cells. Together with the GSH depletion-enhanced photodynamic therapy (PDT), an ideal synergistic tumor therapy for MCF-7 breast cancer via ferroptosis is achieved. In this research, the therapeutic efficacy was significantly improved in terms of enhanced combined anti-tumor efficiency and reduced side effects by responding to significant abnormalities such as high concentrations of GSH in the tumor microenvironment (TME). The Royal Society of Chemistry 2023-01-04 /pmc/articles/PMC9906711/ /pubmed/36794183 http://dx.doi.org/10.1039/d2sc05732h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Li, Wen-Yan
Wan, Jing-Jing
Kan, Jing-Lan
Wang, Bo
Song, Tian
Guan, Qun
Zhou, Le-Le
Li, Yan-An
Dong, Yu-Bin
A biodegradable covalent organic framework for synergistic tumor therapy
title A biodegradable covalent organic framework for synergistic tumor therapy
title_full A biodegradable covalent organic framework for synergistic tumor therapy
title_fullStr A biodegradable covalent organic framework for synergistic tumor therapy
title_full_unstemmed A biodegradable covalent organic framework for synergistic tumor therapy
title_short A biodegradable covalent organic framework for synergistic tumor therapy
title_sort biodegradable covalent organic framework for synergistic tumor therapy
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9906711/
https://www.ncbi.nlm.nih.gov/pubmed/36794183
http://dx.doi.org/10.1039/d2sc05732h
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