A panoramic view on synthetic applications of α-oxothioamides: a highly regioselective synthesis of 2-acyl-4-(het)arylthiazoles and thioethers

Highly regioselective synthesis of 2-acyl-4-(het)arylthiazoles and thioethers by the reaction between α-oxothioamides and α-bromoketones in the absence of base in DMF and in the presence of triethylamine in acetonitrile, respectively, has been reported. This thiazole synthesis is an important extend...

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Autores principales: Suresh, Rajaghatta N., Swaroop, Toreshettahally R., Gowda, Darshini, Mantelingu, Kempegowda, Rangappa, Kanchugarakoppal S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9906803/
https://www.ncbi.nlm.nih.gov/pubmed/36762078
http://dx.doi.org/10.1039/d2ra08118k
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author Suresh, Rajaghatta N.
Swaroop, Toreshettahally R.
Gowda, Darshini
Mantelingu, Kempegowda
Rangappa, Kanchugarakoppal S.
author_facet Suresh, Rajaghatta N.
Swaroop, Toreshettahally R.
Gowda, Darshini
Mantelingu, Kempegowda
Rangappa, Kanchugarakoppal S.
author_sort Suresh, Rajaghatta N.
collection PubMed
description Highly regioselective synthesis of 2-acyl-4-(het)arylthiazoles and thioethers by the reaction between α-oxothioamides and α-bromoketones in the absence of base in DMF and in the presence of triethylamine in acetonitrile, respectively, has been reported. This thiazole synthesis is an important extended work of the Hantzsch thiazole synthesis, which overcomes the drawbacks of earlier reported methods. The probable mechanisms for the formation of thiazoles and thioethers are also presented.
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spelling pubmed-99068032023-02-08 A panoramic view on synthetic applications of α-oxothioamides: a highly regioselective synthesis of 2-acyl-4-(het)arylthiazoles and thioethers Suresh, Rajaghatta N. Swaroop, Toreshettahally R. Gowda, Darshini Mantelingu, Kempegowda Rangappa, Kanchugarakoppal S. RSC Adv Chemistry Highly regioselective synthesis of 2-acyl-4-(het)arylthiazoles and thioethers by the reaction between α-oxothioamides and α-bromoketones in the absence of base in DMF and in the presence of triethylamine in acetonitrile, respectively, has been reported. This thiazole synthesis is an important extended work of the Hantzsch thiazole synthesis, which overcomes the drawbacks of earlier reported methods. The probable mechanisms for the formation of thiazoles and thioethers are also presented. The Royal Society of Chemistry 2023-02-08 /pmc/articles/PMC9906803/ /pubmed/36762078 http://dx.doi.org/10.1039/d2ra08118k Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Suresh, Rajaghatta N.
Swaroop, Toreshettahally R.
Gowda, Darshini
Mantelingu, Kempegowda
Rangappa, Kanchugarakoppal S.
A panoramic view on synthetic applications of α-oxothioamides: a highly regioselective synthesis of 2-acyl-4-(het)arylthiazoles and thioethers
title A panoramic view on synthetic applications of α-oxothioamides: a highly regioselective synthesis of 2-acyl-4-(het)arylthiazoles and thioethers
title_full A panoramic view on synthetic applications of α-oxothioamides: a highly regioselective synthesis of 2-acyl-4-(het)arylthiazoles and thioethers
title_fullStr A panoramic view on synthetic applications of α-oxothioamides: a highly regioselective synthesis of 2-acyl-4-(het)arylthiazoles and thioethers
title_full_unstemmed A panoramic view on synthetic applications of α-oxothioamides: a highly regioselective synthesis of 2-acyl-4-(het)arylthiazoles and thioethers
title_short A panoramic view on synthetic applications of α-oxothioamides: a highly regioselective synthesis of 2-acyl-4-(het)arylthiazoles and thioethers
title_sort panoramic view on synthetic applications of α-oxothioamides: a highly regioselective synthesis of 2-acyl-4-(het)arylthiazoles and thioethers
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9906803/
https://www.ncbi.nlm.nih.gov/pubmed/36762078
http://dx.doi.org/10.1039/d2ra08118k
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