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A case of ascetic fluid Mycobacterium aubagnense infection in a patient with severe peritoneal effusion
BACKGROUND: Mycobacterium aubagnense, which was first characterized in 2006, is a non-tuberculosis mycobacterium (NTM) that has only been isolated from respiratory secretions and joint fluid. With only four cases globally, the microbe has rarely been reported in human clinical cases and the strain h...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9906817/ https://www.ncbi.nlm.nih.gov/pubmed/36750816 http://dx.doi.org/10.1186/s12879-023-08041-1 |
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author | Du, Yuanqin Huang, Jingjing Nong, Yaobin Zhong, Ruixi Zhu, Ronghuo Song, Wenxuan Huang, Hongna Tan, Qinwen Xu, Jian Xiao, Xiyu Jia, Juhong |
author_facet | Du, Yuanqin Huang, Jingjing Nong, Yaobin Zhong, Ruixi Zhu, Ronghuo Song, Wenxuan Huang, Hongna Tan, Qinwen Xu, Jian Xiao, Xiyu Jia, Juhong |
author_sort | Du, Yuanqin |
collection | PubMed |
description | BACKGROUND: Mycobacterium aubagnense, which was first characterized in 2006, is a non-tuberculosis mycobacterium (NTM) that has only been isolated from respiratory secretions and joint fluid. With only four cases globally, the microbe has rarely been reported in human clinical cases and the strain has not been isolated from ascites. CASE PRESENTATION: To the best of our knowledge, this is the first time that M. aubagnense has been isolated from ascites samples of a patient with severe peritoneal effusion and normal liver functions. Anti-NTM therapy with moxifloxacin, ethambutol, and isoniazid combined with furosemide and spironolactone diuretic therapy relieved the symptoms after six months. CONCLUSIONS: Increased puncture and drainage of ascites combined with diuretic treatment did not significantly relieve the ascites, leading to relapse with aggravated symptoms. The subsequent anti-NTM treatment with moxifloxacin, ethambutol, and isoniazid alleviated the degree of ascites. Therefore, we postulated that M. aubagnense infection was the potential cause of the difficult reduction of ascites in this patient. However, the ascites repeatedly occurred in the patient, which was attributed to M. aubagnense resistance due to insufficient medication time and repeated medication. The patient's underlying diseases may also result in ascites. Therefore, there is a need for careful analysis of the clinical significance of M. aubagnense. |
format | Online Article Text |
id | pubmed-9906817 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-99068172023-02-08 A case of ascetic fluid Mycobacterium aubagnense infection in a patient with severe peritoneal effusion Du, Yuanqin Huang, Jingjing Nong, Yaobin Zhong, Ruixi Zhu, Ronghuo Song, Wenxuan Huang, Hongna Tan, Qinwen Xu, Jian Xiao, Xiyu Jia, Juhong BMC Infect Dis Case Report BACKGROUND: Mycobacterium aubagnense, which was first characterized in 2006, is a non-tuberculosis mycobacterium (NTM) that has only been isolated from respiratory secretions and joint fluid. With only four cases globally, the microbe has rarely been reported in human clinical cases and the strain has not been isolated from ascites. CASE PRESENTATION: To the best of our knowledge, this is the first time that M. aubagnense has been isolated from ascites samples of a patient with severe peritoneal effusion and normal liver functions. Anti-NTM therapy with moxifloxacin, ethambutol, and isoniazid combined with furosemide and spironolactone diuretic therapy relieved the symptoms after six months. CONCLUSIONS: Increased puncture and drainage of ascites combined with diuretic treatment did not significantly relieve the ascites, leading to relapse with aggravated symptoms. The subsequent anti-NTM treatment with moxifloxacin, ethambutol, and isoniazid alleviated the degree of ascites. Therefore, we postulated that M. aubagnense infection was the potential cause of the difficult reduction of ascites in this patient. However, the ascites repeatedly occurred in the patient, which was attributed to M. aubagnense resistance due to insufficient medication time and repeated medication. The patient's underlying diseases may also result in ascites. Therefore, there is a need for careful analysis of the clinical significance of M. aubagnense. BioMed Central 2023-02-07 /pmc/articles/PMC9906817/ /pubmed/36750816 http://dx.doi.org/10.1186/s12879-023-08041-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Case Report Du, Yuanqin Huang, Jingjing Nong, Yaobin Zhong, Ruixi Zhu, Ronghuo Song, Wenxuan Huang, Hongna Tan, Qinwen Xu, Jian Xiao, Xiyu Jia, Juhong A case of ascetic fluid Mycobacterium aubagnense infection in a patient with severe peritoneal effusion |
title | A case of ascetic fluid Mycobacterium aubagnense infection in a patient with severe peritoneal effusion |
title_full | A case of ascetic fluid Mycobacterium aubagnense infection in a patient with severe peritoneal effusion |
title_fullStr | A case of ascetic fluid Mycobacterium aubagnense infection in a patient with severe peritoneal effusion |
title_full_unstemmed | A case of ascetic fluid Mycobacterium aubagnense infection in a patient with severe peritoneal effusion |
title_short | A case of ascetic fluid Mycobacterium aubagnense infection in a patient with severe peritoneal effusion |
title_sort | case of ascetic fluid mycobacterium aubagnense infection in a patient with severe peritoneal effusion |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9906817/ https://www.ncbi.nlm.nih.gov/pubmed/36750816 http://dx.doi.org/10.1186/s12879-023-08041-1 |
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