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Shining the light on mesenchymal stem cell-derived exosomes in breast cancer

In women, breast cancer (BC) is the second most frequently diagnosed cancer and the leading cause of cancer death. Mesenchymal stem cells (MSCs) are a subgroup of heterogeneous non-hematopoietic fibroblast-like cells that have the ability to differentiate into multiple cell types. Recent studies sta...

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Autores principales: Al-Awsi, Ghaidaa Raheem Lateef, Alsaikhan, Fahad, Margiana, Ria, Ahmad, Irfan, Patra, Indrajit, Najm, Mazin A. A., Yasin, Ghulam, Rasulova, Iroda, Hammid, Ali Thaeer, Kzar, Hamzah H., Al-Gazally, Moaed E., Siahmansouri, Homayoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9906907/
https://www.ncbi.nlm.nih.gov/pubmed/36750912
http://dx.doi.org/10.1186/s13287-023-03245-3
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author Al-Awsi, Ghaidaa Raheem Lateef
Alsaikhan, Fahad
Margiana, Ria
Ahmad, Irfan
Patra, Indrajit
Najm, Mazin A. A.
Yasin, Ghulam
Rasulova, Iroda
Hammid, Ali Thaeer
Kzar, Hamzah H.
Al-Gazally, Moaed E.
Siahmansouri, Homayoon
author_facet Al-Awsi, Ghaidaa Raheem Lateef
Alsaikhan, Fahad
Margiana, Ria
Ahmad, Irfan
Patra, Indrajit
Najm, Mazin A. A.
Yasin, Ghulam
Rasulova, Iroda
Hammid, Ali Thaeer
Kzar, Hamzah H.
Al-Gazally, Moaed E.
Siahmansouri, Homayoon
author_sort Al-Awsi, Ghaidaa Raheem Lateef
collection PubMed
description In women, breast cancer (BC) is the second most frequently diagnosed cancer and the leading cause of cancer death. Mesenchymal stem cells (MSCs) are a subgroup of heterogeneous non-hematopoietic fibroblast-like cells that have the ability to differentiate into multiple cell types. Recent studies stated that MSCs can migrate into the tumor sites and exert various effect on tumor growth and development. Multiple researches have demonstrated that MSCs can favor tumor growth, while other groups have indicated that MSCs inhibit tumor development. Emerging evidences showed exosomes (Exo) as a new mechanism of cell communication which are essential for the crosstalk between MSCs and BC cells. MSC-derived Exo (MSCs-Exo) could mimic the numerous effects on the proliferation, metastasis, and drug response through carrying a wide scale of molecules, such as proteins, lipids, messenger RNAs, and microRNAs to BC cells. Consequently, in the present literature, we summarized the biogenesis and cargo of Exo and reviewed the role of MSCs-Exo in development of BC.
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spelling pubmed-99069072023-02-08 Shining the light on mesenchymal stem cell-derived exosomes in breast cancer Al-Awsi, Ghaidaa Raheem Lateef Alsaikhan, Fahad Margiana, Ria Ahmad, Irfan Patra, Indrajit Najm, Mazin A. A. Yasin, Ghulam Rasulova, Iroda Hammid, Ali Thaeer Kzar, Hamzah H. Al-Gazally, Moaed E. Siahmansouri, Homayoon Stem Cell Res Ther Review In women, breast cancer (BC) is the second most frequently diagnosed cancer and the leading cause of cancer death. Mesenchymal stem cells (MSCs) are a subgroup of heterogeneous non-hematopoietic fibroblast-like cells that have the ability to differentiate into multiple cell types. Recent studies stated that MSCs can migrate into the tumor sites and exert various effect on tumor growth and development. Multiple researches have demonstrated that MSCs can favor tumor growth, while other groups have indicated that MSCs inhibit tumor development. Emerging evidences showed exosomes (Exo) as a new mechanism of cell communication which are essential for the crosstalk between MSCs and BC cells. MSC-derived Exo (MSCs-Exo) could mimic the numerous effects on the proliferation, metastasis, and drug response through carrying a wide scale of molecules, such as proteins, lipids, messenger RNAs, and microRNAs to BC cells. Consequently, in the present literature, we summarized the biogenesis and cargo of Exo and reviewed the role of MSCs-Exo in development of BC. BioMed Central 2023-02-08 /pmc/articles/PMC9906907/ /pubmed/36750912 http://dx.doi.org/10.1186/s13287-023-03245-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Al-Awsi, Ghaidaa Raheem Lateef
Alsaikhan, Fahad
Margiana, Ria
Ahmad, Irfan
Patra, Indrajit
Najm, Mazin A. A.
Yasin, Ghulam
Rasulova, Iroda
Hammid, Ali Thaeer
Kzar, Hamzah H.
Al-Gazally, Moaed E.
Siahmansouri, Homayoon
Shining the light on mesenchymal stem cell-derived exosomes in breast cancer
title Shining the light on mesenchymal stem cell-derived exosomes in breast cancer
title_full Shining the light on mesenchymal stem cell-derived exosomes in breast cancer
title_fullStr Shining the light on mesenchymal stem cell-derived exosomes in breast cancer
title_full_unstemmed Shining the light on mesenchymal stem cell-derived exosomes in breast cancer
title_short Shining the light on mesenchymal stem cell-derived exosomes in breast cancer
title_sort shining the light on mesenchymal stem cell-derived exosomes in breast cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9906907/
https://www.ncbi.nlm.nih.gov/pubmed/36750912
http://dx.doi.org/10.1186/s13287-023-03245-3
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