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Factors associated with health-related quality of life in patients with Crohn's disease in Iran: A prospective observational study

This was a 1-year prospective observational study of the health-related quality of life (HRQoL) of moderate to severe crohn's disease (CD) patients in Iran. Patients' HRQoL were measured using the EQ-5D 3L, EQ-VAS, and IBDQ-9 tools. HRQoL among CD patients were compared using the T-test, M...

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Autores principales: Karami, Hassan, Shirvani Shiri, Maryam, Ebadi Fard Azar, Farbod, Bagheri Lankarani, Kamran, Ghahramani, Sulmaz, Rezapour, Aziz, Tatari, Maryam, Heidari Javargi, Zahra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907090/
https://www.ncbi.nlm.nih.gov/pubmed/36760884
http://dx.doi.org/10.3389/fmed.2022.1091330
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author Karami, Hassan
Shirvani Shiri, Maryam
Ebadi Fard Azar, Farbod
Bagheri Lankarani, Kamran
Ghahramani, Sulmaz
Rezapour, Aziz
Tatari, Maryam
Heidari Javargi, Zahra
author_facet Karami, Hassan
Shirvani Shiri, Maryam
Ebadi Fard Azar, Farbod
Bagheri Lankarani, Kamran
Ghahramani, Sulmaz
Rezapour, Aziz
Tatari, Maryam
Heidari Javargi, Zahra
author_sort Karami, Hassan
collection PubMed
description This was a 1-year prospective observational study of the health-related quality of life (HRQoL) of moderate to severe crohn's disease (CD) patients in Iran. Patients' HRQoL were measured using the EQ-5D 3L, EQ-VAS, and IBDQ-9 tools. HRQoL among CD patients were compared using the T-test, Mann–Whitney, Chi-square, and Fisher's exact tests. To discover factors influencing patients' HRQoL, multivariate linear regression and multivariate logistic regression tests were utilized. The study included 222 CD patients, with a mean age of 34.67 and mean disease duration of 7.32 years. The dimensions with the worst reported “relatively or extreme problems” were P/D: 77.5% and A/D: 63.1%. Employment, having “other chronic diseases,” and ADA consumption were the most important independent predictors of HRQoL in CD patients, [β = 0.21 (EQ-5D index), β = 19.61 (EQ-VAS), β = 12.26 (IBDQ-9), OR: 0.09 (MO), OR: 0.12 (UA), OR: 0.21 (P/D), OR: 0.22 (A/D)], [β = −0.15 (EQ-5D index), β = −5.84 (IBDQ-9), β = −11.06 (EQ-VAS), OR: 4.20 (MO), OR: 6.50 (UA)], and [OR: 2.29 (A/D)], respectively. Unemployment, presence of “other chronic conditions” had the greatest negative impact on HRQoL of CD patients. There were significant differences in the probability of reporting “relatively or extreme problems” in the SC and A/D dimensions between patients using adalimumab (ADA) and infliximab (IFX).
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spelling pubmed-99070902023-02-08 Factors associated with health-related quality of life in patients with Crohn's disease in Iran: A prospective observational study Karami, Hassan Shirvani Shiri, Maryam Ebadi Fard Azar, Farbod Bagheri Lankarani, Kamran Ghahramani, Sulmaz Rezapour, Aziz Tatari, Maryam Heidari Javargi, Zahra Front Med (Lausanne) Medicine This was a 1-year prospective observational study of the health-related quality of life (HRQoL) of moderate to severe crohn's disease (CD) patients in Iran. Patients' HRQoL were measured using the EQ-5D 3L, EQ-VAS, and IBDQ-9 tools. HRQoL among CD patients were compared using the T-test, Mann–Whitney, Chi-square, and Fisher's exact tests. To discover factors influencing patients' HRQoL, multivariate linear regression and multivariate logistic regression tests were utilized. The study included 222 CD patients, with a mean age of 34.67 and mean disease duration of 7.32 years. The dimensions with the worst reported “relatively or extreme problems” were P/D: 77.5% and A/D: 63.1%. Employment, having “other chronic diseases,” and ADA consumption were the most important independent predictors of HRQoL in CD patients, [β = 0.21 (EQ-5D index), β = 19.61 (EQ-VAS), β = 12.26 (IBDQ-9), OR: 0.09 (MO), OR: 0.12 (UA), OR: 0.21 (P/D), OR: 0.22 (A/D)], [β = −0.15 (EQ-5D index), β = −5.84 (IBDQ-9), β = −11.06 (EQ-VAS), OR: 4.20 (MO), OR: 6.50 (UA)], and [OR: 2.29 (A/D)], respectively. Unemployment, presence of “other chronic conditions” had the greatest negative impact on HRQoL of CD patients. There were significant differences in the probability of reporting “relatively or extreme problems” in the SC and A/D dimensions between patients using adalimumab (ADA) and infliximab (IFX). Frontiers Media S.A. 2023-01-19 /pmc/articles/PMC9907090/ /pubmed/36760884 http://dx.doi.org/10.3389/fmed.2022.1091330 Text en Copyright © 2023 Karami, Shirvani Shiri, Ebadi Fard Azar, Bagheri Lankarani, Ghahramani, Rezapour, Tatari and Heidari Javargi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Karami, Hassan
Shirvani Shiri, Maryam
Ebadi Fard Azar, Farbod
Bagheri Lankarani, Kamran
Ghahramani, Sulmaz
Rezapour, Aziz
Tatari, Maryam
Heidari Javargi, Zahra
Factors associated with health-related quality of life in patients with Crohn's disease in Iran: A prospective observational study
title Factors associated with health-related quality of life in patients with Crohn's disease in Iran: A prospective observational study
title_full Factors associated with health-related quality of life in patients with Crohn's disease in Iran: A prospective observational study
title_fullStr Factors associated with health-related quality of life in patients with Crohn's disease in Iran: A prospective observational study
title_full_unstemmed Factors associated with health-related quality of life in patients with Crohn's disease in Iran: A prospective observational study
title_short Factors associated with health-related quality of life in patients with Crohn's disease in Iran: A prospective observational study
title_sort factors associated with health-related quality of life in patients with crohn's disease in iran: a prospective observational study
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907090/
https://www.ncbi.nlm.nih.gov/pubmed/36760884
http://dx.doi.org/10.3389/fmed.2022.1091330
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