FXR mediates ILC-intrinsic responses to intestinal inflammation

The pleiotropic actions of the Farnesoid X Receptor (FXR) are required for gut health, and reciprocally, reduced intestinal FXR signaling is seen in inflammatory bowel diseases (IBDs). Here, we show that activation of FXR selectively in the intestine is protective in inflammation-driven models of IB...

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Detalles Bibliográficos
Autores principales: Fu, Ting, Li, Yuwenbin, Oh, Tae Gyu, Cayabyab, Fritz, He, Nanhai, Tang, Qin, Coulter, Sally, Truitt, Morgan, Medina, Paul, He, Mingxiao, Yu, Ruth T., Atkins, Annette, Zheng, Ye, Liddle, Christopher, Downes, Michael, Evans, Ronald M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907109/
https://www.ncbi.nlm.nih.gov/pubmed/36508655
http://dx.doi.org/10.1073/pnas.2213041119

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