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A smartphone intervention that enhances real-world memory and promotes differentiation of hippocampal activity in older adults

The act of remembering an everyday experience influences how we interpret the world, how we think about the future, and how we perceive ourselves. It also enhances long-term retention of the recalled content, increasing the likelihood that it will be recalled again. Unfortunately, the ability to rec...

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Detalles Bibliográficos
Autores principales: Martin, Chris B., Hong, Bryan, Newsome, Rachel N., Savel, Katarina, Meade, Melissa E., Xia, Andrew, Honey, Christopher J., Barense, Morgan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907156/
https://www.ncbi.nlm.nih.gov/pubmed/36512503
http://dx.doi.org/10.1073/pnas.2214285119
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author Martin, Chris B.
Hong, Bryan
Newsome, Rachel N.
Savel, Katarina
Meade, Melissa E.
Xia, Andrew
Honey, Christopher J.
Barense, Morgan D.
author_facet Martin, Chris B.
Hong, Bryan
Newsome, Rachel N.
Savel, Katarina
Meade, Melissa E.
Xia, Andrew
Honey, Christopher J.
Barense, Morgan D.
author_sort Martin, Chris B.
collection PubMed
description The act of remembering an everyday experience influences how we interpret the world, how we think about the future, and how we perceive ourselves. It also enhances long-term retention of the recalled content, increasing the likelihood that it will be recalled again. Unfortunately, the ability to recollect event-specific details and reexperience the past tends to decline with age. This decline in recollection may reflect a corresponding decrease in the distinctiveness of hippocampal memory representations. Despite these well-established changes, there are few effective cognitive behavioral interventions that target real-world episodic memory. We addressed this gap by developing a smartphone-based application called HippoCamera that allows participants to record labeled videos of everyday events and subsequently replay, high-fidelity autobiographical memory cues. In two experiments, we found that older adults were able to easily integrate this noninvasive intervention into their daily lives. Using HippoCamera to repeatedly reactivate memories for real-world events improved episodic recollection and it evoked more positive autobiographical sentiment at the time of retrieval. In both experiments, these benefits were observed shortly after the intervention and again after a 3-mo delay. Moreover, more detailed recollection was associated with more differentiated memory signals in the hippocampus. Thus, using this smartphone application to systematically reactivate memories for recent real-world experiences can help to maintain a bridge between the present and past in older adults.
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spelling pubmed-99071562023-02-08 A smartphone intervention that enhances real-world memory and promotes differentiation of hippocampal activity in older adults Martin, Chris B. Hong, Bryan Newsome, Rachel N. Savel, Katarina Meade, Melissa E. Xia, Andrew Honey, Christopher J. Barense, Morgan D. Proc Natl Acad Sci U S A Social Sciences The act of remembering an everyday experience influences how we interpret the world, how we think about the future, and how we perceive ourselves. It also enhances long-term retention of the recalled content, increasing the likelihood that it will be recalled again. Unfortunately, the ability to recollect event-specific details and reexperience the past tends to decline with age. This decline in recollection may reflect a corresponding decrease in the distinctiveness of hippocampal memory representations. Despite these well-established changes, there are few effective cognitive behavioral interventions that target real-world episodic memory. We addressed this gap by developing a smartphone-based application called HippoCamera that allows participants to record labeled videos of everyday events and subsequently replay, high-fidelity autobiographical memory cues. In two experiments, we found that older adults were able to easily integrate this noninvasive intervention into their daily lives. Using HippoCamera to repeatedly reactivate memories for real-world events improved episodic recollection and it evoked more positive autobiographical sentiment at the time of retrieval. In both experiments, these benefits were observed shortly after the intervention and again after a 3-mo delay. Moreover, more detailed recollection was associated with more differentiated memory signals in the hippocampus. Thus, using this smartphone application to systematically reactivate memories for recent real-world experiences can help to maintain a bridge between the present and past in older adults. National Academy of Sciences 2022-12-13 2022-12-20 /pmc/articles/PMC9907156/ /pubmed/36512503 http://dx.doi.org/10.1073/pnas.2214285119 Text en Copyright © 2022 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Social Sciences
Martin, Chris B.
Hong, Bryan
Newsome, Rachel N.
Savel, Katarina
Meade, Melissa E.
Xia, Andrew
Honey, Christopher J.
Barense, Morgan D.
A smartphone intervention that enhances real-world memory and promotes differentiation of hippocampal activity in older adults
title A smartphone intervention that enhances real-world memory and promotes differentiation of hippocampal activity in older adults
title_full A smartphone intervention that enhances real-world memory and promotes differentiation of hippocampal activity in older adults
title_fullStr A smartphone intervention that enhances real-world memory and promotes differentiation of hippocampal activity in older adults
title_full_unstemmed A smartphone intervention that enhances real-world memory and promotes differentiation of hippocampal activity in older adults
title_short A smartphone intervention that enhances real-world memory and promotes differentiation of hippocampal activity in older adults
title_sort smartphone intervention that enhances real-world memory and promotes differentiation of hippocampal activity in older adults
topic Social Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907156/
https://www.ncbi.nlm.nih.gov/pubmed/36512503
http://dx.doi.org/10.1073/pnas.2214285119
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