Cargando…
Metals to combat antimicrobial resistance
Bacteria, similar to most organisms, have a love–hate relationship with metals: a specific metal may be essential for survival yet toxic in certain forms and concentrations. Metal ions have a long history of antimicrobial activity and have received increasing attention in recent years owing to the r...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907218/ https://www.ncbi.nlm.nih.gov/pubmed/37117903 http://dx.doi.org/10.1038/s41570-023-00463-4 |
_version_ | 1784884131078864896 |
---|---|
author | Frei, Angelo Verderosa, Anthony D. Elliott, Alysha G. Zuegg, Johannes Blaskovich, Mark A. T. |
author_facet | Frei, Angelo Verderosa, Anthony D. Elliott, Alysha G. Zuegg, Johannes Blaskovich, Mark A. T. |
author_sort | Frei, Angelo |
collection | PubMed |
description | Bacteria, similar to most organisms, have a love–hate relationship with metals: a specific metal may be essential for survival yet toxic in certain forms and concentrations. Metal ions have a long history of antimicrobial activity and have received increasing attention in recent years owing to the rise of antimicrobial resistance. The search for antibacterial agents now encompasses metal ions, nanoparticles and metal complexes with antimicrobial activity (‘metalloantibiotics’). Although yet to be advanced to the clinic, metalloantibiotics are a vast and underexplored group of compounds that could lead to a much-needed new class of antibiotics. This Review summarizes recent developments in this growing field, focusing on advances in the development of metalloantibiotics, in particular, those for which the mechanism of action has been investigated. We also provide an overview of alternative uses of metal complexes to combat bacterial infections, including antimicrobial photodynamic therapy and radionuclide diagnosis of bacterial infections. [Image: see text] |
format | Online Article Text |
id | pubmed-9907218 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-99072182023-02-09 Metals to combat antimicrobial resistance Frei, Angelo Verderosa, Anthony D. Elliott, Alysha G. Zuegg, Johannes Blaskovich, Mark A. T. Nat Rev Chem Review Article Bacteria, similar to most organisms, have a love–hate relationship with metals: a specific metal may be essential for survival yet toxic in certain forms and concentrations. Metal ions have a long history of antimicrobial activity and have received increasing attention in recent years owing to the rise of antimicrobial resistance. The search for antibacterial agents now encompasses metal ions, nanoparticles and metal complexes with antimicrobial activity (‘metalloantibiotics’). Although yet to be advanced to the clinic, metalloantibiotics are a vast and underexplored group of compounds that could lead to a much-needed new class of antibiotics. This Review summarizes recent developments in this growing field, focusing on advances in the development of metalloantibiotics, in particular, those for which the mechanism of action has been investigated. We also provide an overview of alternative uses of metal complexes to combat bacterial infections, including antimicrobial photodynamic therapy and radionuclide diagnosis of bacterial infections. [Image: see text] Nature Publishing Group UK 2023-02-08 2023 /pmc/articles/PMC9907218/ /pubmed/37117903 http://dx.doi.org/10.1038/s41570-023-00463-4 Text en © Springer Nature Limited 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Article Frei, Angelo Verderosa, Anthony D. Elliott, Alysha G. Zuegg, Johannes Blaskovich, Mark A. T. Metals to combat antimicrobial resistance |
title | Metals to combat antimicrobial resistance |
title_full | Metals to combat antimicrobial resistance |
title_fullStr | Metals to combat antimicrobial resistance |
title_full_unstemmed | Metals to combat antimicrobial resistance |
title_short | Metals to combat antimicrobial resistance |
title_sort | metals to combat antimicrobial resistance |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907218/ https://www.ncbi.nlm.nih.gov/pubmed/37117903 http://dx.doi.org/10.1038/s41570-023-00463-4 |
work_keys_str_mv | AT freiangelo metalstocombatantimicrobialresistance AT verderosaanthonyd metalstocombatantimicrobialresistance AT elliottalyshag metalstocombatantimicrobialresistance AT zueggjohannes metalstocombatantimicrobialresistance AT blaskovichmarkat metalstocombatantimicrobialresistance |