Binding peptide generation for MHC Class I proteins with deep reinforcement learning

MOTIVATION: MHC Class I protein plays an important role in immunotherapy by presenting immunogenic peptides to anti-tumor immune cells. The repertoires of peptides for various MHC Class I proteins are distinct, which can be reflected by their diverse binding motifs. To characterize binding motifs fo...

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Detalles Bibliográficos
Autores principales: Chen, Ziqi, Zhang, Baoyi, Guo, Hongyu, Emani, Prashant, Clancy, Trevor, Jiang, Chongming, Gerstein, Mark, Ning, Xia, Cheng, Chao, Min, Martin Renqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907221/
https://www.ncbi.nlm.nih.gov/pubmed/36692135
http://dx.doi.org/10.1093/bioinformatics/btad055

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907221/
https://www.ncbi.nlm.nih.gov/pubmed/36692135
http://dx.doi.org/10.1093/bioinformatics/btad055

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