Rho Kinase Inhibitor AR-12286 Reverses Steroid-Induced Changes in Intraocular Pressure, Effective Filtration Areas, and Morphology in Mouse Eyes

PURPOSE: We investigated mechanisms of reduction of intraocular pressure (IOP) by Rho kinase inhibitor AR-12286 in steroid-induced ocular hypertension (SIOH). METHODS: C57BL/6 mice (N = 56) were randomly divided into Saline, dexamethasone (DEX), DEX + AR-12286, and DEX-discontinuation (DEX-DC) group...

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Detalles Bibliográficos
Autores principales: Ren, Ruiyi, Humphrey, Anne A., Kopczynski, Casey, Gong, Haiyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2023
Materias:
Physiology and Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907372/
https://www.ncbi.nlm.nih.gov/pubmed/36734964
http://dx.doi.org/10.1167/iovs.64.2.7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907372/
https://www.ncbi.nlm.nih.gov/pubmed/36734964
http://dx.doi.org/10.1167/iovs.64.2.7

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