Cargando…

Rho Kinase Inhibitor AR-12286 Reverses Steroid-Induced Changes in Intraocular Pressure, Effective Filtration Areas, and Morphology in Mouse Eyes

PURPOSE: We investigated mechanisms of reduction of intraocular pressure (IOP) by Rho kinase inhibitor AR-12286 in steroid-induced ocular hypertension (SIOH). METHODS: C57BL/6 mice (N = 56) were randomly divided into Saline, dexamethasone (DEX), DEX + AR-12286, and DEX-discontinuation (DEX-DC) group...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ren, Ruiyi, Humphrey, Anne A., Kopczynski, Casey, Gong, Haiyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2023
Materias:	Physiology and Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907372/ https://www.ncbi.nlm.nih.gov/pubmed/36734964 http://dx.doi.org/10.1167/iovs.64.2.7

Ejemplares similares

Relationships between Intraocular Pressure, Effective Filtration Area, and Morphological Changes in the Trabecular Meshwork of Steroid-Induced Ocular Hypertensive Mouse Eyes
por: Ren, Ruiyi, et al.
Publicado: (2022)

AR12286 Alleviates TGF-β-Related Myofibroblast Transdifferentiation and Reduces Fibrosis after Glaucoma Filtration Surgery
por: Cheng, Wen-Sheng, et al.
Publicado: (2020)

Physical symptoms and brain morphology: a population neuroimaging study in 12,286 pre-adolescents
por: Estévez-López, Fernando, et al.
Publicado: (2023)

Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms
por: Ren, Ruiyi, et al.
Publicado: (2016)

Effects of Topical Latanoprost on Intraocular Pressure and Myopia Progression in Young Guinea Pigs
por: El-Nimri, Nevin W., et al.
Publicado: (2018)

Effect of AR-13324 on Episcleral Venous Pressure in Dutch Belted Rabbits
por: Kiel, Jeffrey W., et al.
Publicado: (2015)

Constriction of Retinal Venules to Endothelin-1: Obligatory Roles of ET(A) Receptors, Extracellular Calcium Entry, and Rho Kinase
por: Chen, Yen-Lin, et al.
Publicado: (2018)

Trabodenoson, an Adenosine Mimetic With A(1) Receptor Selectivity Lowers Intraocular Pressure by Increasing Conventional Outflow Facility in Mice
por: Li, Guorong, et al.
Publicado: (2018)

A Small Molecule Inhibitor of VE-PTP Activates Tie2 in Schlemm's Canal Increasing Outflow Facility and Reducing Intraocular Pressure
por: Li, Guorong, et al.
Publicado: (2020)

Reverse Remodeling in Human Heart Failure after Cardiac Resynchronization Therapy Is Associated With Reduced RHO-Kinase Activation
por: Ocaranza, Maria Paz, et al.
Publicado: (2021)

Anti-fibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis
por: Li, Guorong, et al.
Publicado: (2021)

Subconjunctival Lymphatics Respond to VEGFC and Anti-Metabolites in Rabbit and Mouse Eyes
por: Lee, Jong Yeon, et al.
Publicado: (2022)

NCX 667, a Novel Nitric Oxide Donor, Lowers Intraocular Pressure in Rabbits, Dogs, and Non-Human Primates and Enhances TGFβ2-Induced Outflow in HTM/HSC Constructs
por: Bastia, Elena, et al.
Publicado: (2021)

Eye Drops of Metformin Prevents Fibrosis After Glaucoma Filtration Surgery in Rats via Activating AMPK/Nrf2 Signaling Pathway
por: Li, Xueru, et al.
Publicado: (2020)

The “C3aR Antagonist” SB290157 is a Partial C5aR2 Agonist
por: Li, Xaria X., et al.
Publicado: (2021)

Effect of Topical Phenylephrine 2.5% on Episcleral Venous Pressure in Normal Human Eyes
por: Kazemi, Arash, et al.
Publicado: (2021)

Modeling the Glomerular Filtration Barrier and Intercellular Crosstalk
por: Ebefors, Kerstin, et al.
Publicado: (2021)

The Soluble Guanylate Cyclase Stimulator IWP-953 Increases Conventional Outflow Facility in Mouse Eyes
por: Ge, Pei, et al.
Publicado: (2016)

TRPV1 and TRPM8 Channels and Nocifensive Behavior in a Rat Model for Dry Eye
por: Bereiter, David A., et al.
Publicado: (2018)

Pathogenic Mechanism of Dry Eye–Induced Chronic Ocular Pain and a Mechanism-Based Therapeutic Approach
por: Tei, Yuto, et al.
Publicado: (2022)

Antidepressant effects of ginsenoside Rf on behavioral change in the glial degeneration model of depression by reversing glial loss
por: Kim, Yunna, et al.
Publicado: (2020)

The Eye Drop Preservative Benzalkonium Chloride Potently Induces Mitochondrial Dysfunction and Preferentially Affects LHON Mutant Cells
por: Datta, Sandipan, et al.
Publicado: (2017)

RhoA improves cryopreservation of rooster sperm through the Rho/RhoA-associated kinase/cofilin pathway
por: Heng, Nuo, et al.
Publicado: (2022)

Beneficial Effects of Combined AT(1) Receptor/Neprilysin Inhibition (ARNI) Versus AT(1) Receptor Blockade Alone in the Diabetic Eye
por: Prasad, Tuhina, et al.
Publicado: (2016)

Pro-Secretory Activity and Pharmacology in Rabbits of an Aminophenyl-1,3,5-Triazine CFTR Activator for Dry Eye Disorders
por: Felix, Christian M., et al.
Publicado: (2017)

Proteomic analyses reveal that ginsenoside Rg3(S) partially reverses cellular senescence in human dermal fibroblasts by inducing peroxiredoxin
por: Jang, Ik-Soon, et al.
Publicado: (2020)

Differences in Outflow Facility Between Angiographically Identified High- Versus Low-Flow Regions of the Conventional Outflow Pathways in Porcine Eyes
por: Strohmaier, Clemens A., et al.
Publicado: (2023)

Phase 3 Clinical Trial Comparing the Safety and Efficacy of Netarsudil to Ripasudil in Patients with Primary Open-Angle Glaucoma or Ocular Hypertension: Japan Rho Kinase Elevated Intraocular Pressure Treatment Trial (J-ROCKET)
por: Araie, Makoto, et al.
Publicado: (2023)

Stereoisomer-specific ginsenoside 20(S)-Rg3 reverses replicative senescence of human diploid fibroblasts via Akt-mTOR-Sirtuin signaling
por: Yang, Kyeong-Eun, et al.
Publicado: (2020)

Incidence of presumed steroid response in contralateral eye of patients who underwent glaucoma filtration surgery
por: Pandit, Rinal, et al.
Publicado: (2021)

A Study on the Drug Concentration in Fellow Eyes After Unilateral Intravitreal Injection of Conbercept Into New Zealand Rabbit Eyes
por: Di, Yu, et al.
Publicado: (2021)

Spatio-Temporal Regulation of RhoGTPases Signaling by Myosin II
por: Wu, Selwin K., et al.
Publicado: (2019)

The regulation and function of the striated muscle activator of rho signaling (STARS) protein
por: Wallace, Marita A., et al.
Publicado: (2012)

Rho-Kinase Inhibition Ameliorates Dasatinib-Induced Endothelial Dysfunction and Pulmonary Hypertension
por: Fazakas, Csilla, et al.
Publicado: (2018)

Effects of intubation with a double-lumen endotracheal tube on intraocular pressure during rapid sequence induction using succinylcholine chloride in patients with or without underlying systemic hypertension
por: Park, Chan-oh, et al.
Publicado: (2019)

Innovative Nanoparticles Enhance N-Palmitoylethanolamide Intraocular Delivery
por: Puglia, Carmelo, et al.
Publicado: (2018)

Axon growth inhibition by RhoA/ROCK in the central nervous system
por: Fujita, Yuki, et al.
Publicado: (2014)

Rho, a Fraction From Rhodiola crenulate, Ameliorates Hepatic Steatosis in Mice Models
por: Yi, Qin, et al.
Publicado: (2018)

Intraocular pressure effect of intravitreal conbercept injection for retinopathy of prematurity
por: Gao, Caifeng, et al.
Publicado: (2023)

Therapeutic Targets for Treatment of Heart Failure: Focus on GRKs and β-Arrestins Affecting βAR Signaling
por: Mangmool, Supachoke, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_uab67qg6vh2qb92vhiep0a2e1q