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Tuberculosis Molecular Bacterial Load Assay Reveals Early Delayed Bacterial Killing in Patients With Relapse
Bacterial killing in patients with tuberculosis (TB) relapse was compared to that in patients achieving cure, measured by TB molecular bacterial load assay (TB-MBLA) or mycobacteria growth indicator tube (MGIT) time to positivity (TTP). TB-MBLA in 4 relapsed patients was significantly different comp...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907486/ https://www.ncbi.nlm.nih.gov/pubmed/35717643 http://dx.doi.org/10.1093/cid/ciac445 |
| _version_ | 1784884181948432384 |
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| author | Ntinginya, Nyanda Elias Bakuli, Abhishek Mapamba, Daniel Sabiiti, Wilber Kibiki, Gibson Minja, Lilian Tina Kuchaka, Davis Reither, Klaus Phillips, Patrick Peter John Boeree, Martin Johan Gillespie, Stephen H Hoelscher, Michael Heinrich, Norbert |
| author_facet | Ntinginya, Nyanda Elias Bakuli, Abhishek Mapamba, Daniel Sabiiti, Wilber Kibiki, Gibson Minja, Lilian Tina Kuchaka, Davis Reither, Klaus Phillips, Patrick Peter John Boeree, Martin Johan Gillespie, Stephen H Hoelscher, Michael Heinrich, Norbert |
| author_sort | Ntinginya, Nyanda Elias |
| collection | PubMed |
| description | Bacterial killing in patients with tuberculosis (TB) relapse was compared to that in patients achieving cure, measured by TB molecular bacterial load assay (TB-MBLA) or mycobacteria growth indicator tube (MGIT) time to positivity (TTP). TB-MBLA in 4 relapsed patients was significantly different compared to 132 cured patients after 2 weeks of treatment; MGIT TTP showed a significant difference from week 8. |
| format | Online Article Text |
| id | pubmed-9907486 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Oxford University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-99074862023-02-09 Tuberculosis Molecular Bacterial Load Assay Reveals Early Delayed Bacterial Killing in Patients With Relapse Ntinginya, Nyanda Elias Bakuli, Abhishek Mapamba, Daniel Sabiiti, Wilber Kibiki, Gibson Minja, Lilian Tina Kuchaka, Davis Reither, Klaus Phillips, Patrick Peter John Boeree, Martin Johan Gillespie, Stephen H Hoelscher, Michael Heinrich, Norbert Clin Infect Dis Brief Report Bacterial killing in patients with tuberculosis (TB) relapse was compared to that in patients achieving cure, measured by TB molecular bacterial load assay (TB-MBLA) or mycobacteria growth indicator tube (MGIT) time to positivity (TTP). TB-MBLA in 4 relapsed patients was significantly different compared to 132 cured patients after 2 weeks of treatment; MGIT TTP showed a significant difference from week 8. Oxford University Press 2022-06-19 /pmc/articles/PMC9907486/ /pubmed/35717643 http://dx.doi.org/10.1093/cid/ciac445 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
| spellingShingle | Brief Report Ntinginya, Nyanda Elias Bakuli, Abhishek Mapamba, Daniel Sabiiti, Wilber Kibiki, Gibson Minja, Lilian Tina Kuchaka, Davis Reither, Klaus Phillips, Patrick Peter John Boeree, Martin Johan Gillespie, Stephen H Hoelscher, Michael Heinrich, Norbert Tuberculosis Molecular Bacterial Load Assay Reveals Early Delayed Bacterial Killing in Patients With Relapse |
| title | Tuberculosis Molecular Bacterial Load Assay Reveals Early Delayed Bacterial Killing in Patients With Relapse |
| title_full | Tuberculosis Molecular Bacterial Load Assay Reveals Early Delayed Bacterial Killing in Patients With Relapse |
| title_fullStr | Tuberculosis Molecular Bacterial Load Assay Reveals Early Delayed Bacterial Killing in Patients With Relapse |
| title_full_unstemmed | Tuberculosis Molecular Bacterial Load Assay Reveals Early Delayed Bacterial Killing in Patients With Relapse |
| title_short | Tuberculosis Molecular Bacterial Load Assay Reveals Early Delayed Bacterial Killing in Patients With Relapse |
| title_sort | tuberculosis molecular bacterial load assay reveals early delayed bacterial killing in patients with relapse |
| topic | Brief Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907486/ https://www.ncbi.nlm.nih.gov/pubmed/35717643 http://dx.doi.org/10.1093/cid/ciac445 |
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