Modeling-Based Response-Guided Hepatitis C Treatment During Pregnancy and Postpartum

Treating hepatitis C virus (HCV) in pregnancy would address HCV during prenatal care and potentially reduce the risk of vertical transmission. Response-guided therapy could provide a means to individualize and the reduce duration of HCV treatment during pregnancy. Data from a 27-year-old woman indic...

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Autores principales: Kushner, Tatyana, Nyabanga, Custon T, Cotler, Scott J, Etzion, Ohad, Dahari, Harel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907544/
https://www.ncbi.nlm.nih.gov/pubmed/36776773
http://dx.doi.org/10.1093/ofid/ofad027
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author Kushner, Tatyana
Nyabanga, Custon T
Cotler, Scott J
Etzion, Ohad
Dahari, Harel
author_facet Kushner, Tatyana
Nyabanga, Custon T
Cotler, Scott J
Etzion, Ohad
Dahari, Harel
author_sort Kushner, Tatyana
collection PubMed
description Treating hepatitis C virus (HCV) in pregnancy would address HCV during prenatal care and potentially reduce the risk of vertical transmission. Response-guided therapy could provide a means to individualize and the reduce duration of HCV treatment during pregnancy. Data from a 27-year-old woman indicated that, pretreatment, HCV was stable and that it dropped in a biphasic manner during sofosbuvir/velpatasvir therapy, reaching target not detected at time of delivery—16 days post–initiation of therapy. Mathematical modeling of measured HCV at days 0, 7, and 14 predicted that cure could have been achieved after 7 weeks of sofosbuvir/velpatasvir, reducing the duration of therapy by 5 weeks.
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spelling pubmed-99075442023-02-09 Modeling-Based Response-Guided Hepatitis C Treatment During Pregnancy and Postpartum Kushner, Tatyana Nyabanga, Custon T Cotler, Scott J Etzion, Ohad Dahari, Harel Open Forum Infect Dis Brief Report Treating hepatitis C virus (HCV) in pregnancy would address HCV during prenatal care and potentially reduce the risk of vertical transmission. Response-guided therapy could provide a means to individualize and the reduce duration of HCV treatment during pregnancy. Data from a 27-year-old woman indicated that, pretreatment, HCV was stable and that it dropped in a biphasic manner during sofosbuvir/velpatasvir therapy, reaching target not detected at time of delivery—16 days post–initiation of therapy. Mathematical modeling of measured HCV at days 0, 7, and 14 predicted that cure could have been achieved after 7 weeks of sofosbuvir/velpatasvir, reducing the duration of therapy by 5 weeks. Oxford University Press 2023-01-20 /pmc/articles/PMC9907544/ /pubmed/36776773 http://dx.doi.org/10.1093/ofid/ofad027 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Kushner, Tatyana
Nyabanga, Custon T
Cotler, Scott J
Etzion, Ohad
Dahari, Harel
Modeling-Based Response-Guided Hepatitis C Treatment During Pregnancy and Postpartum
title Modeling-Based Response-Guided Hepatitis C Treatment During Pregnancy and Postpartum
title_full Modeling-Based Response-Guided Hepatitis C Treatment During Pregnancy and Postpartum
title_fullStr Modeling-Based Response-Guided Hepatitis C Treatment During Pregnancy and Postpartum
title_full_unstemmed Modeling-Based Response-Guided Hepatitis C Treatment During Pregnancy and Postpartum
title_short Modeling-Based Response-Guided Hepatitis C Treatment During Pregnancy and Postpartum
title_sort modeling-based response-guided hepatitis c treatment during pregnancy and postpartum
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907544/
https://www.ncbi.nlm.nih.gov/pubmed/36776773
http://dx.doi.org/10.1093/ofid/ofad027
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