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Skin barrier response to active chlorine hand disinfectant—An experimental study comparing skin barrier response to active chlorine hand disinfectant and alcohol‐based hand rub on healthy skin and eczematous skin

BACKGROUND: Alcohol‐based hand rub (ABHR) is widely used for hand disinfection in the health care sector. ABHR is, however, known to cause discomfort when applied on damaged skin emphasizing the unmet need for alternative and better tolerated types of disinfectants. Active chlorine hand disinfectant...

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Autores principales: Yüksel, Yasemin Topal, Sonne, Mie, Nørreslet, Line Brok, Gundersen, Glenn, Fazli, Magnus Mustafa, Agner, Tove
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907602/
https://www.ncbi.nlm.nih.gov/pubmed/34420240
http://dx.doi.org/10.1111/srt.13096
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author Yüksel, Yasemin Topal
Sonne, Mie
Nørreslet, Line Brok
Gundersen, Glenn
Fazli, Magnus Mustafa
Agner, Tove
author_facet Yüksel, Yasemin Topal
Sonne, Mie
Nørreslet, Line Brok
Gundersen, Glenn
Fazli, Magnus Mustafa
Agner, Tove
author_sort Yüksel, Yasemin Topal
collection PubMed
description BACKGROUND: Alcohol‐based hand rub (ABHR) is widely used for hand disinfection in the health care sector. ABHR is, however, known to cause discomfort when applied on damaged skin emphasizing the unmet need for alternative and better tolerated types of disinfectants. Active chlorine hand disinfectants (ACHDs) are potential new candidates; however, the effect on the skin barrier function compared to ABHR remains to be assessed. MATERIALS AND METHODS: In Study A, the forearm skin of healthy adults was repeatedly exposed to ACHD and ABHR. Skin barrier function was assessed by measurement of transepidermal water loss, electrical conductance, pH, and erythema at baseline and at follow‐up after 2 days, and subjective discomfort was likewise assessed. Study B was performed in the same way; however, in order to induce an experimental irritant contact dermatitis, sodium lauryl sulfate patch tests were applied to forearms before exposure to ACHD and ABHR. RESULTS: In both studies, the skin barrier function was unaffected after repetitive exposure to ACHD and ABHR, and with no significant differences between the products. Subjective discomfort was reported as sporadic or very mild in relation to both products. CONCLUSION: Our results illustrate that use of ACHD does not affect the skin barrier function negatively, neither in intact skin nor in skin with experimentally induced contact dermatitis. Future studies should include real‐life evaluation of skin barrier function and subjective discomfort following ACHD use in individuals with and without hand eczema.
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spelling pubmed-99076022023-04-13 Skin barrier response to active chlorine hand disinfectant—An experimental study comparing skin barrier response to active chlorine hand disinfectant and alcohol‐based hand rub on healthy skin and eczematous skin Yüksel, Yasemin Topal Sonne, Mie Nørreslet, Line Brok Gundersen, Glenn Fazli, Magnus Mustafa Agner, Tove Skin Res Technol Original Articles BACKGROUND: Alcohol‐based hand rub (ABHR) is widely used for hand disinfection in the health care sector. ABHR is, however, known to cause discomfort when applied on damaged skin emphasizing the unmet need for alternative and better tolerated types of disinfectants. Active chlorine hand disinfectants (ACHDs) are potential new candidates; however, the effect on the skin barrier function compared to ABHR remains to be assessed. MATERIALS AND METHODS: In Study A, the forearm skin of healthy adults was repeatedly exposed to ACHD and ABHR. Skin barrier function was assessed by measurement of transepidermal water loss, electrical conductance, pH, and erythema at baseline and at follow‐up after 2 days, and subjective discomfort was likewise assessed. Study B was performed in the same way; however, in order to induce an experimental irritant contact dermatitis, sodium lauryl sulfate patch tests were applied to forearms before exposure to ACHD and ABHR. RESULTS: In both studies, the skin barrier function was unaffected after repetitive exposure to ACHD and ABHR, and with no significant differences between the products. Subjective discomfort was reported as sporadic or very mild in relation to both products. CONCLUSION: Our results illustrate that use of ACHD does not affect the skin barrier function negatively, neither in intact skin nor in skin with experimentally induced contact dermatitis. Future studies should include real‐life evaluation of skin barrier function and subjective discomfort following ACHD use in individuals with and without hand eczema. John Wiley and Sons Inc. 2021-08-22 /pmc/articles/PMC9907602/ /pubmed/34420240 http://dx.doi.org/10.1111/srt.13096 Text en © 2021 The Authors. Skin Research and Technology published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Yüksel, Yasemin Topal
Sonne, Mie
Nørreslet, Line Brok
Gundersen, Glenn
Fazli, Magnus Mustafa
Agner, Tove
Skin barrier response to active chlorine hand disinfectant—An experimental study comparing skin barrier response to active chlorine hand disinfectant and alcohol‐based hand rub on healthy skin and eczematous skin
title Skin barrier response to active chlorine hand disinfectant—An experimental study comparing skin barrier response to active chlorine hand disinfectant and alcohol‐based hand rub on healthy skin and eczematous skin
title_full Skin barrier response to active chlorine hand disinfectant—An experimental study comparing skin barrier response to active chlorine hand disinfectant and alcohol‐based hand rub on healthy skin and eczematous skin
title_fullStr Skin barrier response to active chlorine hand disinfectant—An experimental study comparing skin barrier response to active chlorine hand disinfectant and alcohol‐based hand rub on healthy skin and eczematous skin
title_full_unstemmed Skin barrier response to active chlorine hand disinfectant—An experimental study comparing skin barrier response to active chlorine hand disinfectant and alcohol‐based hand rub on healthy skin and eczematous skin
title_short Skin barrier response to active chlorine hand disinfectant—An experimental study comparing skin barrier response to active chlorine hand disinfectant and alcohol‐based hand rub on healthy skin and eczematous skin
title_sort skin barrier response to active chlorine hand disinfectant—an experimental study comparing skin barrier response to active chlorine hand disinfectant and alcohol‐based hand rub on healthy skin and eczematous skin
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907602/
https://www.ncbi.nlm.nih.gov/pubmed/34420240
http://dx.doi.org/10.1111/srt.13096
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