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Association between vitamin D concentration and delirium in hospitalized patients: A meta-analysis

BACKGROUND: Now the occurrence of delirium is more concerning to clinicians and psychiatrists. It has been reported that vitamin D deficiency may be a relevant factor in the development of delirium in hospitalized patients. STUDY OBJECTIVE: To investigate the association between vitamin D concentrat...

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Autores principales: Fu, Ningning, Miao, Mengrong, Li, Ningning, Zeng, Shuang, Zhu, Ruilou, Zhang, Jiaqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907811/
https://www.ncbi.nlm.nih.gov/pubmed/36753475
http://dx.doi.org/10.1371/journal.pone.0281313
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author Fu, Ningning
Miao, Mengrong
Li, Ningning
Zeng, Shuang
Zhu, Ruilou
Zhang, Jiaqiang
author_facet Fu, Ningning
Miao, Mengrong
Li, Ningning
Zeng, Shuang
Zhu, Ruilou
Zhang, Jiaqiang
author_sort Fu, Ningning
collection PubMed
description BACKGROUND: Now the occurrence of delirium is more concerning to clinicians and psychiatrists. It has been reported that vitamin D deficiency may be a relevant factor in the development of delirium in hospitalized patients. STUDY OBJECTIVE: To investigate the association between vitamin D concentration and delirium in hospitalized patients. DESIGN: Meta-analysis. METHODS: A systematic literature search was conducted using PubMed, EMBASE, and the Cochrane Library. The primary outcome was the occurrence of delirium in the inpatient setting. Odds ratios (OR) were calculated with random or fixed effects models. RESULTS: In this article, we define the normal range of vitamin D concentrations as greater than 75 nmol / L, 50–75 nmol / L as vitamin D insufficiency, 25–50 nmol / L as vitamin D deficiency, and less than 25 nmol / L as vitamin D severe deficiency. The Results showed that severe vitamin D deficiency (OR: 1.98 [1.41–2.79], P<0.001) and vitamin D deficiency (OR: 1.50 [1.12–2.00], P = 0.006) were more likely to develop delirium than normal vitamin D levels. Subgroup analysis also revealed that low vitamin D concentrations were associated with a higher incidence of delirium, whether the cutoff point was 25 nmol/L (OR: 1.52 [1.40–1.64], P<0.001), 50 nmol/L (OR: 1.47 [1.19–1.82], P<0.001), or 75 nmol/L (OR: 1.54 [1.21–1.96], P<0.001). The included studies scored medium and high on the Newcastle-Ottawa quality assessment scale. CONCLUSION: Compared with normal vitamin D levels, severe vitamin D deficiency and vitamin D deficiency, but not vitamin D insufficiency, are associated with a higher incidence of delirium in hospitalized patients. TRIAL REGISTRATION: This review was registered in the PROSPERO database under identifier CRD42021271347. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021271347.
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spelling pubmed-99078112023-02-08 Association between vitamin D concentration and delirium in hospitalized patients: A meta-analysis Fu, Ningning Miao, Mengrong Li, Ningning Zeng, Shuang Zhu, Ruilou Zhang, Jiaqiang PLoS One Research Article BACKGROUND: Now the occurrence of delirium is more concerning to clinicians and psychiatrists. It has been reported that vitamin D deficiency may be a relevant factor in the development of delirium in hospitalized patients. STUDY OBJECTIVE: To investigate the association between vitamin D concentration and delirium in hospitalized patients. DESIGN: Meta-analysis. METHODS: A systematic literature search was conducted using PubMed, EMBASE, and the Cochrane Library. The primary outcome was the occurrence of delirium in the inpatient setting. Odds ratios (OR) were calculated with random or fixed effects models. RESULTS: In this article, we define the normal range of vitamin D concentrations as greater than 75 nmol / L, 50–75 nmol / L as vitamin D insufficiency, 25–50 nmol / L as vitamin D deficiency, and less than 25 nmol / L as vitamin D severe deficiency. The Results showed that severe vitamin D deficiency (OR: 1.98 [1.41–2.79], P<0.001) and vitamin D deficiency (OR: 1.50 [1.12–2.00], P = 0.006) were more likely to develop delirium than normal vitamin D levels. Subgroup analysis also revealed that low vitamin D concentrations were associated with a higher incidence of delirium, whether the cutoff point was 25 nmol/L (OR: 1.52 [1.40–1.64], P<0.001), 50 nmol/L (OR: 1.47 [1.19–1.82], P<0.001), or 75 nmol/L (OR: 1.54 [1.21–1.96], P<0.001). The included studies scored medium and high on the Newcastle-Ottawa quality assessment scale. CONCLUSION: Compared with normal vitamin D levels, severe vitamin D deficiency and vitamin D deficiency, but not vitamin D insufficiency, are associated with a higher incidence of delirium in hospitalized patients. TRIAL REGISTRATION: This review was registered in the PROSPERO database under identifier CRD42021271347. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021271347. Public Library of Science 2023-02-08 /pmc/articles/PMC9907811/ /pubmed/36753475 http://dx.doi.org/10.1371/journal.pone.0281313 Text en © 2023 Fu et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Fu, Ningning
Miao, Mengrong
Li, Ningning
Zeng, Shuang
Zhu, Ruilou
Zhang, Jiaqiang
Association between vitamin D concentration and delirium in hospitalized patients: A meta-analysis
title Association between vitamin D concentration and delirium in hospitalized patients: A meta-analysis
title_full Association between vitamin D concentration and delirium in hospitalized patients: A meta-analysis
title_fullStr Association between vitamin D concentration and delirium in hospitalized patients: A meta-analysis
title_full_unstemmed Association between vitamin D concentration and delirium in hospitalized patients: A meta-analysis
title_short Association between vitamin D concentration and delirium in hospitalized patients: A meta-analysis
title_sort association between vitamin d concentration and delirium in hospitalized patients: a meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907811/
https://www.ncbi.nlm.nih.gov/pubmed/36753475
http://dx.doi.org/10.1371/journal.pone.0281313
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