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Exposure to occupational risk factors is associated with the severity and progression of chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) results from a complex interaction between genes and the environment, and occupational exposures are an underappreciated risk factor. Until now, little research attention has been paid to the potential impact of occupational risk factor exposure on the CO...

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Autores principales: Chen, Yao, Peng, Cong, Zhang, Hua, Cai, Yu, Yuan, Rui, Song, Pingping, Zhang, Chunling, Yan, Yongjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907959/
https://www.ncbi.nlm.nih.gov/pubmed/36820577
http://dx.doi.org/10.1097/MD.0000000000032908
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author Chen, Yao
Peng, Cong
Zhang, Hua
Cai, Yu
Yuan, Rui
Song, Pingping
Zhang, Chunling
Yan, Yongjian
author_facet Chen, Yao
Peng, Cong
Zhang, Hua
Cai, Yu
Yuan, Rui
Song, Pingping
Zhang, Chunling
Yan, Yongjian
author_sort Chen, Yao
collection PubMed
description Chronic obstructive pulmonary disease (COPD) results from a complex interaction between genes and the environment, and occupational exposures are an underappreciated risk factor. Until now, little research attention has been paid to the potential impact of occupational risk factor exposure on the COPD in China. The aim of this retrospective study was to analyze the role of occupational risk factor exposure on the severity and progression of COPD for exploring new prevention strategies for this disease. This study adopted a random cluster-sampling method. Five grade-A tertiary hospitals that met the inclusion criteria were selected as the survey sites, and patients with COPD hospitalized in these hospitals from January 1, 2019, to December 31, 2019, were selected as the research subjects. Data of the patients diagnosed with COPD met the Global Initiative for Chronic Obstructive Lung Disease (2019) criteria and were collected from the computerized medical record databases. Among 4082 investigated COPD patients, 1063 (26%) were found to have occupational risk factor exposure history. The top 3 industries with a large COPD case number and a history of occupational risk factor exposure ranked in the order of agriculture (including farming, forestry, animal husbandry, and fishery), manufacturing, and mining. Further multivariate logistic regression analysis indicated that when setting a low exposure level as a reference, medium and high exposure levels were correlated with the severity of COPD (odds ratio values were 2.837 and 6.201, respectively, P < .05). Linear regression analysis showed that cumulative exposure to occupational risk factors was negatively correlated with the forced expiratory volume in 1-second percentage of COPD patients, with a correlation coefficient of 0.68. Our results indicated that occupational risk factor exposure levels were related to the severity of COPD significantly. The incubation period of COPD in the exposure group was significantly shorter than that in the non-exposure group. To prevent worked-related COPD, special attention and control efforts should be taken to reduce the level of occupational risk factors such as organic dust, irritating chemicals, etc in the work environments, especially in the industries of agriculture, forestry, animal husbandry and fishery, manufacturing, and mining.
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spelling pubmed-99079592023-02-10 Exposure to occupational risk factors is associated with the severity and progression of chronic obstructive pulmonary disease Chen, Yao Peng, Cong Zhang, Hua Cai, Yu Yuan, Rui Song, Pingping Zhang, Chunling Yan, Yongjian Medicine (Baltimore) 6600 Chronic obstructive pulmonary disease (COPD) results from a complex interaction between genes and the environment, and occupational exposures are an underappreciated risk factor. Until now, little research attention has been paid to the potential impact of occupational risk factor exposure on the COPD in China. The aim of this retrospective study was to analyze the role of occupational risk factor exposure on the severity and progression of COPD for exploring new prevention strategies for this disease. This study adopted a random cluster-sampling method. Five grade-A tertiary hospitals that met the inclusion criteria were selected as the survey sites, and patients with COPD hospitalized in these hospitals from January 1, 2019, to December 31, 2019, were selected as the research subjects. Data of the patients diagnosed with COPD met the Global Initiative for Chronic Obstructive Lung Disease (2019) criteria and were collected from the computerized medical record databases. Among 4082 investigated COPD patients, 1063 (26%) were found to have occupational risk factor exposure history. The top 3 industries with a large COPD case number and a history of occupational risk factor exposure ranked in the order of agriculture (including farming, forestry, animal husbandry, and fishery), manufacturing, and mining. Further multivariate logistic regression analysis indicated that when setting a low exposure level as a reference, medium and high exposure levels were correlated with the severity of COPD (odds ratio values were 2.837 and 6.201, respectively, P < .05). Linear regression analysis showed that cumulative exposure to occupational risk factors was negatively correlated with the forced expiratory volume in 1-second percentage of COPD patients, with a correlation coefficient of 0.68. Our results indicated that occupational risk factor exposure levels were related to the severity of COPD significantly. The incubation period of COPD in the exposure group was significantly shorter than that in the non-exposure group. To prevent worked-related COPD, special attention and control efforts should be taken to reduce the level of occupational risk factors such as organic dust, irritating chemicals, etc in the work environments, especially in the industries of agriculture, forestry, animal husbandry and fishery, manufacturing, and mining. Lippincott Williams & Wilkins 2023-02-10 /pmc/articles/PMC9907959/ /pubmed/36820577 http://dx.doi.org/10.1097/MD.0000000000032908 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 6600
Chen, Yao
Peng, Cong
Zhang, Hua
Cai, Yu
Yuan, Rui
Song, Pingping
Zhang, Chunling
Yan, Yongjian
Exposure to occupational risk factors is associated with the severity and progression of chronic obstructive pulmonary disease
title Exposure to occupational risk factors is associated with the severity and progression of chronic obstructive pulmonary disease
title_full Exposure to occupational risk factors is associated with the severity and progression of chronic obstructive pulmonary disease
title_fullStr Exposure to occupational risk factors is associated with the severity and progression of chronic obstructive pulmonary disease
title_full_unstemmed Exposure to occupational risk factors is associated with the severity and progression of chronic obstructive pulmonary disease
title_short Exposure to occupational risk factors is associated with the severity and progression of chronic obstructive pulmonary disease
title_sort exposure to occupational risk factors is associated with the severity and progression of chronic obstructive pulmonary disease
topic 6600
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907959/
https://www.ncbi.nlm.nih.gov/pubmed/36820577
http://dx.doi.org/10.1097/MD.0000000000032908
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