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New strategy in hemorrhagic gastric cancer: A case report of complete pathological remission after neoadjuvant chemotherapy

Strategy for hemorrhagic gastric cancer should both handle the potential life-threatening situation caused by bleeding and increase probability of long-term survival. For hemorrhagic patients with locally advanced gastric cancer, surgical resection is always the preferred option for the reason that...

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Autores principales: Zhou, Yuhang, Zhou, Yuchen, Lin, Xiaojun, Lin, Shengtao, Li, Weihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907999/
https://www.ncbi.nlm.nih.gov/pubmed/36820602
http://dx.doi.org/10.1097/MD.0000000000032789
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author Zhou, Yuhang
Zhou, Yuchen
Lin, Xiaojun
Lin, Shengtao
Li, Weihua
author_facet Zhou, Yuhang
Zhou, Yuchen
Lin, Xiaojun
Lin, Shengtao
Li, Weihua
author_sort Zhou, Yuhang
collection PubMed
description Strategy for hemorrhagic gastric cancer should both handle the potential life-threatening situation caused by bleeding and increase probability of long-term survival. For hemorrhagic patients with locally advanced gastric cancer, surgical resection is always the preferred option for the reason that it eliminates both the tumor and risk of rebleeding. However, the long-term survival after resection is still unsatisfactory. PATIENT CONCERNS: Here, we report a patient with hemorrhagic locally advanced gastric cancer achieved pathological complete response after neoadjuvant chemotherapy. DIAGNOSES: In this case, a 58-year-old man presenting with gastrointestinal hemorrhage and hemodynamic instability was admitted to the emergency department. Gastroscopy and biopsy revealed a large hemorrhagic ulcerated carcinoma located in the antrum, gastric angle, and lower part of gastric body. Abdominal CT indicated an infiltrative ulcerated carcinoma with perigastric lymph nodes metastasis. INTERVENTIONS: After fluid resuscitation, blood transfusion, application of proton pump inhibitors, and Octreotide, the patient recovered gradually. Then, nasojejunal feeding tube was placed for enteral nutrition and tumor exclusion. Subsequently, the patient received 5 cycles of neoadjuvant S-1 plus oxaliplatin regimen, without signs of rebleeding, followed by radical distal gastrectomy. OUTCOMES: Pathological examination confirmed that the patient received pathological complete response. LESSONS: This case suggests that neoadjuvant chemotherapy is feasible in selected hemorrhagic gastric cancer patients and tumor exclusion is helpful in reducing rebleeding risk.
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spelling pubmed-99079992023-02-10 New strategy in hemorrhagic gastric cancer: A case report of complete pathological remission after neoadjuvant chemotherapy Zhou, Yuhang Zhou, Yuchen Lin, Xiaojun Lin, Shengtao Li, Weihua Medicine (Baltimore) 4500 Strategy for hemorrhagic gastric cancer should both handle the potential life-threatening situation caused by bleeding and increase probability of long-term survival. For hemorrhagic patients with locally advanced gastric cancer, surgical resection is always the preferred option for the reason that it eliminates both the tumor and risk of rebleeding. However, the long-term survival after resection is still unsatisfactory. PATIENT CONCERNS: Here, we report a patient with hemorrhagic locally advanced gastric cancer achieved pathological complete response after neoadjuvant chemotherapy. DIAGNOSES: In this case, a 58-year-old man presenting with gastrointestinal hemorrhage and hemodynamic instability was admitted to the emergency department. Gastroscopy and biopsy revealed a large hemorrhagic ulcerated carcinoma located in the antrum, gastric angle, and lower part of gastric body. Abdominal CT indicated an infiltrative ulcerated carcinoma with perigastric lymph nodes metastasis. INTERVENTIONS: After fluid resuscitation, blood transfusion, application of proton pump inhibitors, and Octreotide, the patient recovered gradually. Then, nasojejunal feeding tube was placed for enteral nutrition and tumor exclusion. Subsequently, the patient received 5 cycles of neoadjuvant S-1 plus oxaliplatin regimen, without signs of rebleeding, followed by radical distal gastrectomy. OUTCOMES: Pathological examination confirmed that the patient received pathological complete response. LESSONS: This case suggests that neoadjuvant chemotherapy is feasible in selected hemorrhagic gastric cancer patients and tumor exclusion is helpful in reducing rebleeding risk. Lippincott Williams & Wilkins 2023-02-10 /pmc/articles/PMC9907999/ /pubmed/36820602 http://dx.doi.org/10.1097/MD.0000000000032789 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 4500
Zhou, Yuhang
Zhou, Yuchen
Lin, Xiaojun
Lin, Shengtao
Li, Weihua
New strategy in hemorrhagic gastric cancer: A case report of complete pathological remission after neoadjuvant chemotherapy
title New strategy in hemorrhagic gastric cancer: A case report of complete pathological remission after neoadjuvant chemotherapy
title_full New strategy in hemorrhagic gastric cancer: A case report of complete pathological remission after neoadjuvant chemotherapy
title_fullStr New strategy in hemorrhagic gastric cancer: A case report of complete pathological remission after neoadjuvant chemotherapy
title_full_unstemmed New strategy in hemorrhagic gastric cancer: A case report of complete pathological remission after neoadjuvant chemotherapy
title_short New strategy in hemorrhagic gastric cancer: A case report of complete pathological remission after neoadjuvant chemotherapy
title_sort new strategy in hemorrhagic gastric cancer: a case report of complete pathological remission after neoadjuvant chemotherapy
topic 4500
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907999/
https://www.ncbi.nlm.nih.gov/pubmed/36820602
http://dx.doi.org/10.1097/MD.0000000000032789
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