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Metabolite asymmetric dimethylarginine (ADMA) functions as a destabilization enhancer of SOX9 mediated by DDAH1 in osteoarthritis

Osteoarthritis (OA) is a degenerative disease with a series of metabolic changes accompanied by many altered enzymes. Here, we report that the down-regulated dimethylarginine dimethylaminohydrolase-1 (DDAH1) is accompanied by increased asymmetric dimethylarginine (ADMA) in degenerated chondrocytes a...

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Detalles Bibliográficos
Autores principales:	Wu, Yizheng, Shen, Shuying, Chen, Jiaxin, Ni, Weiyu, Wang, Qinxin, Zhou, Hongyi, Chen, Junxin, Zhang, Haitao, Mei, Zixuan, Sun, Xuewu, Shen, Panyang, Jie, Zhiwei, Xu, Wenbin, Hong, Zhenghua, Ma, Yan, Wang, Kefan, Wan, Shuanglin, Wu, Hongfei, Xie, Ziang, Qin, An, Fan, Shunwu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908022/ https://www.ncbi.nlm.nih.gov/pubmed/36753544 http://dx.doi.org/10.1126/sciadv.ade5584

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