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Anti-seed PNAs targeting multiple oncomiRs for brain tumor therapy

Glioblastoma (GBM) is one of the most lethal malignancies with poor survival and high recurrence rates. Here, we aimed to simultaneously target oncomiRs 10b and 21, reported to drive GBM progression and invasiveness. We designed short (8-mer) γ-modified peptide nucleic acids (sγPNAs), targeting the...

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Detalles Bibliográficos
Autores principales:	Wang, Yazhe, Malik, Shipra, Suh, Hee-Won, Xiao, Yong, Deng, Yanxiang, Fan, Rong, Huttner, Anita, Bindra, Ranjit S., Singh, Vijender, Saltzman, W. Mark, Bahal, Raman
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908025/ https://www.ncbi.nlm.nih.gov/pubmed/36753549 http://dx.doi.org/10.1126/sciadv.abq7459

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