Single-cell profiling of alveolar rhabdomyosarcoma reveals RAS pathway inhibitors as cell-fate hijackers with therapeutic relevance

Rhabdomyosarcoma (RMS) is a group of pediatric cancers with features of developing skeletal muscle. The cellular hierarchy and mechanisms leading to developmental arrest remain elusive. Here, we combined single-cell RNA sequencing, mass cytometry, and high-content imaging to resolve intratumoral het...

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Detalles Bibliográficos
Autores principales: Danielli, Sara G., Porpiglia, Ermelinda, De Micheli, Andrea J., Navarro, Natalia, Zellinger, Michael J., Bechtold, Ingrid, Kisele, Samanta, Volken, Larissa, Marques, Joana G., Kasper, Stephanie, Bode, Peter K., Henssen, Anton G., Gürgen, Dennis, Delattre, Olivier, Surdez, Didier, Roma, Josep, Bühlmann, Peter, Blau, Helen M., Wachtel, Marco, Schäfer, Beat W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908029/
https://www.ncbi.nlm.nih.gov/pubmed/36753540
http://dx.doi.org/10.1126/sciadv.ade9238

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