IL-4 and helminth infection downregulate MINCLE-dependent macrophage response to mycobacteria and Th17 adjuvanticity

The myeloid C-type lectin receptor (CLR) MINCLE senses the mycobacterial cell wall component trehalose-6,6’-dimycolate (TDM). Recently, we found that IL-4 downregulates MINCLE expression in macrophages. IL-4 is a hallmark cytokine in helminth infections, which appear to increase the risk for mycobac...

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Detalles Bibliográficos
Autores principales: Schick, Judith, Altunay, Meltem, Lacorcia, Matthew, Marschner, Nathalie, Westermann, Stefanie, Schluckebier, Julia, Schubart, Christoph, Bodendorfer, Barbara, Christensen, Dennis, Alexander, Christian, Wirtz, Stefan, Voehringer, David, da Costa, Clarissa Prazeres, Lang, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908076/
https://www.ncbi.nlm.nih.gov/pubmed/36753434
http://dx.doi.org/10.7554/eLife.72923

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