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Initiation of HIV-1 Gag lattice assembly is required for recognition of the viral genome packaging signal

The encapsidation of HIV-1 gRNA into virions is enabled by the binding of the nucleocapsid (NC) domain of the HIV-1 Gag polyprotein to the structured viral RNA packaging signal (Ψ) at the 5’ end of the viral genome. However, the subcellular location and oligomeric status of Gag during the initial Ga...

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Detalles Bibliográficos
Autores principales: Lei, Xiao, Gonçalves-Carneiro, Daniel, Zang, Trinity M, Bieniasz, Paul D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908077/
https://www.ncbi.nlm.nih.gov/pubmed/36688533
http://dx.doi.org/10.7554/eLife.83548