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Scleraxis-lineage cells are required for tendon homeostasis and their depletion induces an accelerated extracellular matrix aging phenotype

Aged tendons have disrupted homeostasis, increased injury risk, and impaired healing capacity. Understanding mechanisms of homeostatic disruption is crucial for developing therapeutics to retain tendon health through the lifespan. Here, we developed a novel model of accelerated tendon extracellular...

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Detalles Bibliográficos
Autores principales: Korcari, Antonion, Nichols, Anne EC, Buckley, Mark R, Loiselle, Alayna E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908079/
https://www.ncbi.nlm.nih.gov/pubmed/36656751
http://dx.doi.org/10.7554/eLife.84194