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Small Intestinal Perforation Caused by Enteric-coated Low-dose Aspirin

A 77-year-old man presented with abdominal pain for 1 week. He was taking enteric-coated low-dose aspirin (LDA) to prevent secondary cardiovascular events and a proton pump inhibitor (PPI). Computed tomography indicated a small intestinal perforation; thus, small intestine resection was performed. T...

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Autores principales: Matsubara, Shohei, Sada, Ken-ei, Sawada, Haruo, Oida, Jiro, Tanaka, Kimiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908378/
https://www.ncbi.nlm.nih.gov/pubmed/35732453
http://dx.doi.org/10.2169/internalmedicine.9681-22
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author Matsubara, Shohei
Sada, Ken-ei
Sawada, Haruo
Oida, Jiro
Tanaka, Kimiaki
author_facet Matsubara, Shohei
Sada, Ken-ei
Sawada, Haruo
Oida, Jiro
Tanaka, Kimiaki
author_sort Matsubara, Shohei
collection PubMed
description A 77-year-old man presented with abdominal pain for 1 week. He was taking enteric-coated low-dose aspirin (LDA) to prevent secondary cardiovascular events and a proton pump inhibitor (PPI). Computed tomography indicated a small intestinal perforation; thus, small intestine resection was performed. Two months after surgery, he experienced a recurrence of the perforation. Since his repeated perforation was suspected to be due to LDA, LDA was discontinued. He has experienced no further recurrence since then. This is the first case of small intestinal perforation caused by enteric-coated LDA. Enteric-coated LDA may cause small intestinal perforation in patients with severe atherosclerosis under PPI administration.
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spelling pubmed-99083782023-02-14 Small Intestinal Perforation Caused by Enteric-coated Low-dose Aspirin Matsubara, Shohei Sada, Ken-ei Sawada, Haruo Oida, Jiro Tanaka, Kimiaki Intern Med Case Report A 77-year-old man presented with abdominal pain for 1 week. He was taking enteric-coated low-dose aspirin (LDA) to prevent secondary cardiovascular events and a proton pump inhibitor (PPI). Computed tomography indicated a small intestinal perforation; thus, small intestine resection was performed. Two months after surgery, he experienced a recurrence of the perforation. Since his repeated perforation was suspected to be due to LDA, LDA was discontinued. He has experienced no further recurrence since then. This is the first case of small intestinal perforation caused by enteric-coated LDA. Enteric-coated LDA may cause small intestinal perforation in patients with severe atherosclerosis under PPI administration. The Japanese Society of Internal Medicine 2022-06-21 2023-01-15 /pmc/articles/PMC9908378/ /pubmed/35732453 http://dx.doi.org/10.2169/internalmedicine.9681-22 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Matsubara, Shohei
Sada, Ken-ei
Sawada, Haruo
Oida, Jiro
Tanaka, Kimiaki
Small Intestinal Perforation Caused by Enteric-coated Low-dose Aspirin
title Small Intestinal Perforation Caused by Enteric-coated Low-dose Aspirin
title_full Small Intestinal Perforation Caused by Enteric-coated Low-dose Aspirin
title_fullStr Small Intestinal Perforation Caused by Enteric-coated Low-dose Aspirin
title_full_unstemmed Small Intestinal Perforation Caused by Enteric-coated Low-dose Aspirin
title_short Small Intestinal Perforation Caused by Enteric-coated Low-dose Aspirin
title_sort small intestinal perforation caused by enteric-coated low-dose aspirin
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908378/
https://www.ncbi.nlm.nih.gov/pubmed/35732453
http://dx.doi.org/10.2169/internalmedicine.9681-22
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