Concurrent de novo Thymoma-associated Paraneoplastic Type 1 Autoimmune Hepatitis and Pure Red Cell Aplasia after Thymectomy: A Case Report and Literature Review

The precise manipulation of immune tolerance is the holy grail of immunotherapies for both autoimmunity and cancer immunity. Thymomas are well known to be associated with autoimmune diseases. The exact mechanism by which autoreactivity is induced after thymectomy remains to be elucidated. We herein...

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Autores principales: Sakata, Rie, Chu, Po-sung, Kawaida, Miho, Emoto, Katsura, Sakurai, Masatoshi, Nishida, Risa, Asakura, Keisuke, Morikawa, Rei, Taniki, Nobuhito, Kataoka, Keisuke, Kanai, Takanori, Nakamoto, Nobuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908397/
https://www.ncbi.nlm.nih.gov/pubmed/35705275
http://dx.doi.org/10.2169/internalmedicine.9743-22
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author Sakata, Rie
Chu, Po-sung
Kawaida, Miho
Emoto, Katsura
Sakurai, Masatoshi
Nishida, Risa
Asakura, Keisuke
Morikawa, Rei
Taniki, Nobuhito
Kataoka, Keisuke
Kanai, Takanori
Nakamoto, Nobuhiro
author_facet Sakata, Rie
Chu, Po-sung
Kawaida, Miho
Emoto, Katsura
Sakurai, Masatoshi
Nishida, Risa
Asakura, Keisuke
Morikawa, Rei
Taniki, Nobuhito
Kataoka, Keisuke
Kanai, Takanori
Nakamoto, Nobuhiro
author_sort Sakata, Rie
collection PubMed
description The precise manipulation of immune tolerance is the holy grail of immunotherapies for both autoimmunity and cancer immunity. Thymomas are well known to be associated with autoimmune diseases. The exact mechanism by which autoreactivity is induced after thymectomy remains to be elucidated. We herein present the case of a 50-year-old lady with concurrent de novo type 1 autoimmune hepatitis (AIH) and pure red cell aplasia (PRCA), 1 month after undergoing a successful total thymectomy for combined squamous cell carcinoma and thymoma (Masaoka stage II). Corticosteroids yielded short-term effects for both AIH and PRCA. Literature on thymoma-associated AIH, an extremely rare immune-related comorbidity, was also reviewed.
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spelling pubmed-99083972023-02-14 Concurrent de novo Thymoma-associated Paraneoplastic Type 1 Autoimmune Hepatitis and Pure Red Cell Aplasia after Thymectomy: A Case Report and Literature Review Sakata, Rie Chu, Po-sung Kawaida, Miho Emoto, Katsura Sakurai, Masatoshi Nishida, Risa Asakura, Keisuke Morikawa, Rei Taniki, Nobuhito Kataoka, Keisuke Kanai, Takanori Nakamoto, Nobuhiro Intern Med Case Report The precise manipulation of immune tolerance is the holy grail of immunotherapies for both autoimmunity and cancer immunity. Thymomas are well known to be associated with autoimmune diseases. The exact mechanism by which autoreactivity is induced after thymectomy remains to be elucidated. We herein present the case of a 50-year-old lady with concurrent de novo type 1 autoimmune hepatitis (AIH) and pure red cell aplasia (PRCA), 1 month after undergoing a successful total thymectomy for combined squamous cell carcinoma and thymoma (Masaoka stage II). Corticosteroids yielded short-term effects for both AIH and PRCA. Literature on thymoma-associated AIH, an extremely rare immune-related comorbidity, was also reviewed. The Japanese Society of Internal Medicine 2022-06-14 2023-01-15 /pmc/articles/PMC9908397/ /pubmed/35705275 http://dx.doi.org/10.2169/internalmedicine.9743-22 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Sakata, Rie
Chu, Po-sung
Kawaida, Miho
Emoto, Katsura
Sakurai, Masatoshi
Nishida, Risa
Asakura, Keisuke
Morikawa, Rei
Taniki, Nobuhito
Kataoka, Keisuke
Kanai, Takanori
Nakamoto, Nobuhiro
Concurrent de novo Thymoma-associated Paraneoplastic Type 1 Autoimmune Hepatitis and Pure Red Cell Aplasia after Thymectomy: A Case Report and Literature Review
title Concurrent de novo Thymoma-associated Paraneoplastic Type 1 Autoimmune Hepatitis and Pure Red Cell Aplasia after Thymectomy: A Case Report and Literature Review
title_full Concurrent de novo Thymoma-associated Paraneoplastic Type 1 Autoimmune Hepatitis and Pure Red Cell Aplasia after Thymectomy: A Case Report and Literature Review
title_fullStr Concurrent de novo Thymoma-associated Paraneoplastic Type 1 Autoimmune Hepatitis and Pure Red Cell Aplasia after Thymectomy: A Case Report and Literature Review
title_full_unstemmed Concurrent de novo Thymoma-associated Paraneoplastic Type 1 Autoimmune Hepatitis and Pure Red Cell Aplasia after Thymectomy: A Case Report and Literature Review
title_short Concurrent de novo Thymoma-associated Paraneoplastic Type 1 Autoimmune Hepatitis and Pure Red Cell Aplasia after Thymectomy: A Case Report and Literature Review
title_sort concurrent de novo thymoma-associated paraneoplastic type 1 autoimmune hepatitis and pure red cell aplasia after thymectomy: a case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908397/
https://www.ncbi.nlm.nih.gov/pubmed/35705275
http://dx.doi.org/10.2169/internalmedicine.9743-22
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