Cargando…

Modulation of the mitochondrial Ca(2+) uniporter complex subunit expression by different shear stress patterns in vascular endothelial cells

Mitochondrial calcium ((m)Ca(2+)) uptake occurs via the Mitochondrial Ca(2+) Uniporter (MCU) complex and plays a critical role in mitochondrial dynamics, mitophagy, and apoptosis. MCU complex activity is in part modulated by the expression of its regulatory subunits. Cardiovascular disease models de...

Descripción completa

Detalles Bibliográficos
Autores principales:	Patel, Akshar, Pietromicca, Julia G., Venkatesan, Manigandan, Maity, Soumya, Bard, Jonathan E., Madesh, Muniswamy, Alevriadou, B. Rita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908435/ https://www.ncbi.nlm.nih.gov/pubmed/36754446 http://dx.doi.org/10.14814/phy2.15588

Ejemplares similares

The mitochondrial Ca(2+) uniporter channel synergizes with fluid shear stress to induce mitochondrial Ca(2+) oscillations
por: Patel, Akshar, et al.
Publicado: (2022)

An essential role for cardiolipin in the stability and function of the mitochondrial calcium uniporter
por: Ghosh, Sagnika, et al.
Publicado: (2020)

Resolving macrophage polarization through distinct Ca(2+) entry channel that maintains intracellular signaling and mitochondrial bioenergetics
por: Nascimento Da Conceicao, Viviane, et al.
Publicado: (2021)

Negative modulation of mitochondrial calcium uniporter complex protects neurons against ferroptosis
por: Marmolejo-Garza, Alejandro, et al.
Publicado: (2023)

Selective inhibition of arginase-2 in endothelial cells but not proximal tubules reduces renal fibrosis
por: Wetzel, Michael D., et al.
Publicado: (2020)

A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics after Hypoxia/Reoxygenation Injury
por: Woods, Joshua J., et al.
Publicado: (2019)

VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release
por: Madesh, Muniswamy, et al.
Publicado: (2001)

Mitochondrial calcium signaling mediated transcriptional regulation of keratin filaments is a critical determinant of melanogenesis
por: Tanwar, Jyoti, et al.
Publicado: (2023)

Functional analysis and importance for host cell infection of the Ca(2+)-conducting subunits of the mitochondrial calcium uniporter of Trypanosoma cruzi
por: Chiurillo, Miguel A., et al.
Publicado: (2019)

The Mitochondrial Ca(2+) Uniporter Complex (MCUC) of Trypanosoma brucei Is a Hetero-oligomer That Contains Novel Subunits Essential for Ca(2+) Uptake
por: Huang, Guozhong, et al.
Publicado: (2018)

Mitochondrial pharmacology turns its sights on the Ca(2+) uniporter
por: Storey, Nina M, et al.
Publicado: (2017)

The mechanism of MICU-dependent gating of the mitochondrial Ca(2+)uniporter
por: Garg, Vivek, et al.
Publicado: (2021)

Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex
por: Tsai, Ming-Feng, et al.
Publicado: (2016)

The Mitochondrial Calcium Uniporter Interacts with Subunit c of the ATP Synthase of Trypanosomes and Humans
por: Huang, Guozhong, et al.
Publicado: (2020)

Homoarginine ameliorates diabetic nephropathy independent of nitric oxide synthase‐3
por: Wetzel, Michael D., et al.
Publicado: (2021)

Mitochondrial fusion and Bid-mediated mitochondrial apoptosis are perturbed by alcohol with distinct dependence on its metabolism
por: Naghdi, Shamim, et al.
Publicado: (2018)

MCU (mitochondrial Ca(2+) uniporter) makes the calcium go round
por: Walters, Grant C., et al.
Publicado: (2022)

The pore-forming subunit MCU of the mitochondrial Ca(2+) uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice
por: Georgiadou, Eleni, et al.
Publicado: (2020)

Structural characterization of the mitochondrial Ca(2+) uniporter provides insights into Ca(2+) uptake and regulation
por: Wu, Wenping, et al.
Publicado: (2021)

Cardiovascular homeostasis dependence on MICU2, a regulatory subunit of the mitochondrial calcium uniporter
por: Bick, Alexander G., et al.
Publicado: (2017)

Correction: Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex
por: Tsai, Ming-Feng, et al.
Publicado: (2017)

Different Roles of Mitochondrial Calcium Uniporter Complex Subunits in Growth and Infectivity of Trypanosoma cruzi
por: Chiurillo, Miguel A., et al.
Publicado: (2017)

Shear stress augments mitochondrial ATP generation that triggers ATP release and Ca(2+) signaling in vascular endothelial cells
por: Yamamoto, Kimiko, et al.
Publicado: (2018)

Structural insights into the Ca(2+)-dependent gating of the human mitochondrial calcium uniporter
por: Wang, Yan, et al.
Publicado: (2020)

Characterization of Membrane Potential Dependency of Mitochondrial Ca(2+) Uptake by an Improved Biophysical Model of Mitochondrial Ca(2+) Uniporter
por: Pradhan, Ranjan K., et al.
Publicado: (2010)

Mitochondrial Ca(2+) uniporter (MCU)-dependent and MCU-independent Ca(2+) channels coexist in the inner mitochondrial membrane
por: Bondarenko, Alexander I., et al.
Publicado: (2013)

The Mitochondrial Ca(2+) uniporter is a central regulator of interorganellar Ca(2+) transfer and NFAT activation
por: Yoast, Ryan E., et al.
Publicado: (2021)

Architecture of the Mitochondrial Calcium Uniporter
por: Oxenoid, Kirill, et al.
Publicado: (2016)

SARS-CoV-2 infection enhances mitochondrial PTP complex activity to perturb cardiac energetics
por: Ramachandran, Karthik, et al.
Publicado: (2022)

Importance of mitochondrial calcium uniporter in high glucose–induced endothelial cell dysfunction
por: Chen, Wei, et al.
Publicado: (2017)

Structures reveal gatekeeping of the mitochondrial Ca(2+) uniporter by MICU1-MICU2
por: Wang, Chongyuan, et al.
Publicado: (2020)

Selective role for superoxide in InsP(3) receptor–mediated mitochondrial dysfunction and endothelial apoptosis
por: Madesh, Muniswamy, et al.
Publicado: (2005)

Role of mitochondrial calcium uniporter‐mediated Ca(2+) and iron accumulation in traumatic brain injury
por: Zhang, Li, et al.
Publicado: (2019)

MICU1 controls cristae junction and spatially anchors mitochondrial Ca(2+) uniporter complex
por: Gottschalk, Benjamin, et al.
Publicado: (2019)

Mitochondrial Calcium uniporters are essential for meiotic progression in mouse oocytes by controlling Ca(2+) entry
por: Zhang, Lu yao, et al.
Publicado: (2021)

Structural basis of Ca(2+) uptake by mitochondrial calcium uniporter in mitochondria: a brief review
por: Yoo, Jiho
Publicado: (2022)

A mitochondrial contribution to anti-inflammatory shear stress signaling in vascular endothelial cells
por: Coon, Brian G., et al.
Publicado: (2022)

The mitochondrial calcium uniporter is necessary for synaptic plasticity and proper mitochondrial morphology and distribution in the distal dendrites of CA2 neurons
por: Pannoni, Katy E., et al.
Publicado: (2023)

Distinct Effects of Mitochondrial Na(+)/Ca(2+) Exchanger Inhibition and Ca(2+) Uniporter Activation on Ca(2+) Sparks and Arrhythmogenesis in Diabetic Rats
por: Velmurugan, Sathya, et al.
Publicado: (2023)

Metabolic adaptation to the chronic loss of Ca(2+) signaling induced by KO of IP(3) receptors or the mitochondrial Ca(2+) uniporter
por: Young, Michael P., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_arq8i6ovpcrr48ihuntpj4jvb1