Glutamatergic dysfunction leads to a hyper-dopaminergic phenotype through deficits in short-term habituation: a mechanism for aberrant salience

Psychosis in disorders like schizophrenia is commonly associated with aberrant salience and elevated striatal dopamine. However, the underlying cause(s) of this hyper-dopaminergic state remain elusive. Various lines of evidence point to glutamatergic dysfunction and impairments in synaptic plasticit...

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Detalles Bibliográficos
Autores principales: Panayi, Marios C., Boerner, Thomas, Jahans-Price, Thomas, Huber, Anna, Sprengel, Rolf, Gilmour, Gary, Sanderson, David J., Harrison, Paul J., Walton, Mark E., Bannerman, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908551/
https://www.ncbi.nlm.nih.gov/pubmed/36460723
http://dx.doi.org/10.1038/s41380-022-01861-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908551/
https://www.ncbi.nlm.nih.gov/pubmed/36460723
http://dx.doi.org/10.1038/s41380-022-01861-8

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