Fyn nanoclustering requires switching to an open conformation and is enhanced by FTLD-Tau biomolecular condensates

Fyn is a Src kinase that controls critical signalling cascades and has been implicated in learning and memory. Postsynaptic enrichment of Fyn underpins synaptotoxicity in dementias such as Alzheimer’s disease and frontotemporal lobar degeneration with Tau pathology (FTLD-Tau). The FLTD P301L mutant...

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Detalles Bibliográficos
Autores principales: Martínez-Mármol, Ramón, Small, Christopher, Jiang, Anmin, Palliyaguru, Tishila, Wallis, Tristan P., Gormal, Rachel S., Sibarita, Jean-Baptiste, Götz, Jürgen, Meunier, Frédéric A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908554/
https://www.ncbi.nlm.nih.gov/pubmed/36258016
http://dx.doi.org/10.1038/s41380-022-01825-y

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