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Is the oxidative potential of components of fine particulate matter surface-mediated?

Redox-active substances in fine particulate matter (PM) contribute to inhalation health risks through their potential to generate reactive oxygen species in epithelial lung lining fluid (ELF). The ELF’s air–liquid interface (ALI) can play an important role in the phase transfer and multi-phase react...

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Autores principales: Baumann, Karsten, Wietzoreck, Marco, Shahpoury, Pourya, Filippi, Alexander, Hildmann, Stefanie, Lelieveld, Steven, Berkemeier, Thomas, Tong, Haijie, Pöschl, Ulrich, Lammel, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908692/
https://www.ncbi.nlm.nih.gov/pubmed/36550248
http://dx.doi.org/10.1007/s11356-022-24897-3
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author Baumann, Karsten
Wietzoreck, Marco
Shahpoury, Pourya
Filippi, Alexander
Hildmann, Stefanie
Lelieveld, Steven
Berkemeier, Thomas
Tong, Haijie
Pöschl, Ulrich
Lammel, Gerhard
author_facet Baumann, Karsten
Wietzoreck, Marco
Shahpoury, Pourya
Filippi, Alexander
Hildmann, Stefanie
Lelieveld, Steven
Berkemeier, Thomas
Tong, Haijie
Pöschl, Ulrich
Lammel, Gerhard
author_sort Baumann, Karsten
collection PubMed
description Redox-active substances in fine particulate matter (PM) contribute to inhalation health risks through their potential to generate reactive oxygen species in epithelial lung lining fluid (ELF). The ELF’s air–liquid interface (ALI) can play an important role in the phase transfer and multi-phase reactions of redox-active PM constituents. We investigated the influence of interfacial processes and properties by scrubbing of coated nano-particles with simulated ELF in a nebulizing mist chamber. Weakly water-soluble redox-active organics abundant in ambient fine PM were reproducibly loaded into ELF via ALI mixing. The resulting oxidative potential (OP) of selected quinones and other PAH derivatives were found to exceed the OP resulting from bulk mixing of the same amounts of redox-active substances and ELF. Our results indicate that the OP of PM components depends not only on the PM substance properties but also on the ELF interface properties and uptake mechanisms. OP measurements based on bulk mixing of phases may not represent the effective OP in the human lung. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11356-022-24897-3.
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spelling pubmed-99086922023-02-10 Is the oxidative potential of components of fine particulate matter surface-mediated? Baumann, Karsten Wietzoreck, Marco Shahpoury, Pourya Filippi, Alexander Hildmann, Stefanie Lelieveld, Steven Berkemeier, Thomas Tong, Haijie Pöschl, Ulrich Lammel, Gerhard Environ Sci Pollut Res Int Short Research and Discussion Article Redox-active substances in fine particulate matter (PM) contribute to inhalation health risks through their potential to generate reactive oxygen species in epithelial lung lining fluid (ELF). The ELF’s air–liquid interface (ALI) can play an important role in the phase transfer and multi-phase reactions of redox-active PM constituents. We investigated the influence of interfacial processes and properties by scrubbing of coated nano-particles with simulated ELF in a nebulizing mist chamber. Weakly water-soluble redox-active organics abundant in ambient fine PM were reproducibly loaded into ELF via ALI mixing. The resulting oxidative potential (OP) of selected quinones and other PAH derivatives were found to exceed the OP resulting from bulk mixing of the same amounts of redox-active substances and ELF. Our results indicate that the OP of PM components depends not only on the PM substance properties but also on the ELF interface properties and uptake mechanisms. OP measurements based on bulk mixing of phases may not represent the effective OP in the human lung. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11356-022-24897-3. Springer Berlin Heidelberg 2022-12-23 2023 /pmc/articles/PMC9908692/ /pubmed/36550248 http://dx.doi.org/10.1007/s11356-022-24897-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Short Research and Discussion Article
Baumann, Karsten
Wietzoreck, Marco
Shahpoury, Pourya
Filippi, Alexander
Hildmann, Stefanie
Lelieveld, Steven
Berkemeier, Thomas
Tong, Haijie
Pöschl, Ulrich
Lammel, Gerhard
Is the oxidative potential of components of fine particulate matter surface-mediated?
title Is the oxidative potential of components of fine particulate matter surface-mediated?
title_full Is the oxidative potential of components of fine particulate matter surface-mediated?
title_fullStr Is the oxidative potential of components of fine particulate matter surface-mediated?
title_full_unstemmed Is the oxidative potential of components of fine particulate matter surface-mediated?
title_short Is the oxidative potential of components of fine particulate matter surface-mediated?
title_sort is the oxidative potential of components of fine particulate matter surface-mediated?
topic Short Research and Discussion Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908692/
https://www.ncbi.nlm.nih.gov/pubmed/36550248
http://dx.doi.org/10.1007/s11356-022-24897-3
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