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Genetic differences between suicide deaths and deaths of undetermined intent
INTRODUCTION: Few, if any, prior studies have considered whether undetermined intent (UDI) deaths and suicide deaths differ with respect to genetic liability for suicidal behavior or psychopathology. METHODS: The authors used Swedish national registry data to identify suicide deaths (N = 31,835) and...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908835/ https://www.ncbi.nlm.nih.gov/pubmed/36314433 http://dx.doi.org/10.1111/sltb.12926 |
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author | Edwards, Alexis C. Ohlsson, Henrik Mościcki, Eve K. Sundquist, Jan Crump, Casey Kendler, Kenneth S. Sundquist, Kristina |
author_facet | Edwards, Alexis C. Ohlsson, Henrik Mościcki, Eve K. Sundquist, Jan Crump, Casey Kendler, Kenneth S. Sundquist, Kristina |
author_sort | Edwards, Alexis C. |
collection | PubMed |
description | INTRODUCTION: Few, if any, prior studies have considered whether undetermined intent (UDI) deaths and suicide deaths differ with respect to genetic liability for suicidal behavior or psychopathology. METHODS: The authors used Swedish national registry data to identify suicide deaths (N = 31,835) and UDI deaths (N = 10,623); sociodemographic covariates; and registrations for psychopathology. Family genetic risk scores (FGRS) were derived for each form of psychopathology. The authors used LASSO models to assess genetic and phenotypic differences across outcomes. RESULTS: In the multivariate LASSO regressions, higher FGRS for major depression, bipolar disorder, and suicide death were associated with lower odds of UDI relative to unambiguous suicide (OR = 0.91–0.95), while those for alcohol and drug use disorders, ADHD, and criminal behavior were associated with higher odds of UDI relative to unambiguous suicide (OR = 1.04–1.12). When the corresponding phenotypic registration status for these outcomes was included in a subsequent model, the associations were attenuated and of small magnitude, but many remained different from OR = 1. CONCLUSIONS: Aggregate genetic differences between unambiguous suicide decedents and UDI deaths are small, particularly when accounting for psychiatric comorbidity, but in some cases, statistically significant. These findings suggest that different analytic treatment of UDI deaths may be warranted depending on the research question. Replication in other samples, and using molecular genetic data, is necessary. |
format | Online Article Text |
id | pubmed-9908835 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99088352023-04-13 Genetic differences between suicide deaths and deaths of undetermined intent Edwards, Alexis C. Ohlsson, Henrik Mościcki, Eve K. Sundquist, Jan Crump, Casey Kendler, Kenneth S. Sundquist, Kristina Suicide Life Threat Behav Original Articles INTRODUCTION: Few, if any, prior studies have considered whether undetermined intent (UDI) deaths and suicide deaths differ with respect to genetic liability for suicidal behavior or psychopathology. METHODS: The authors used Swedish national registry data to identify suicide deaths (N = 31,835) and UDI deaths (N = 10,623); sociodemographic covariates; and registrations for psychopathology. Family genetic risk scores (FGRS) were derived for each form of psychopathology. The authors used LASSO models to assess genetic and phenotypic differences across outcomes. RESULTS: In the multivariate LASSO regressions, higher FGRS for major depression, bipolar disorder, and suicide death were associated with lower odds of UDI relative to unambiguous suicide (OR = 0.91–0.95), while those for alcohol and drug use disorders, ADHD, and criminal behavior were associated with higher odds of UDI relative to unambiguous suicide (OR = 1.04–1.12). When the corresponding phenotypic registration status for these outcomes was included in a subsequent model, the associations were attenuated and of small magnitude, but many remained different from OR = 1. CONCLUSIONS: Aggregate genetic differences between unambiguous suicide decedents and UDI deaths are small, particularly when accounting for psychiatric comorbidity, but in some cases, statistically significant. These findings suggest that different analytic treatment of UDI deaths may be warranted depending on the research question. Replication in other samples, and using molecular genetic data, is necessary. John Wiley and Sons Inc. 2022-10-31 2023-02 /pmc/articles/PMC9908835/ /pubmed/36314433 http://dx.doi.org/10.1111/sltb.12926 Text en © 2022 The Authors. Suicide and Life‐Threatening Behavior published by Wiley Periodicals LLC on behalf of American Association of Suicidology. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Edwards, Alexis C. Ohlsson, Henrik Mościcki, Eve K. Sundquist, Jan Crump, Casey Kendler, Kenneth S. Sundquist, Kristina Genetic differences between suicide deaths and deaths of undetermined intent |
title | Genetic differences between suicide deaths and deaths of undetermined intent |
title_full | Genetic differences between suicide deaths and deaths of undetermined intent |
title_fullStr | Genetic differences between suicide deaths and deaths of undetermined intent |
title_full_unstemmed | Genetic differences between suicide deaths and deaths of undetermined intent |
title_short | Genetic differences between suicide deaths and deaths of undetermined intent |
title_sort | genetic differences between suicide deaths and deaths of undetermined intent |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908835/ https://www.ncbi.nlm.nih.gov/pubmed/36314433 http://dx.doi.org/10.1111/sltb.12926 |
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