Accelerating inhibitor discovery for deubiquitinating enzymes

Deubiquitinating enzymes (DUBs) are an emerging drug target class of ~100 proteases that cleave ubiquitin from protein substrates to regulate many cellular processes. A lack of selective chemical probes impedes pharmacologic interrogation of this important gene family. DUBs engage their cognate liga...

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Detalles Bibliográficos
Autores principales: Chan, Wai Cheung, Liu, Xiaoxi, Magin, Robert S., Girardi, Nicholas M., Ficarro, Scott B., Hu, Wanyi, Tarazona Guzman, Maria I., Starnbach, Cara A., Felix, Alejandra, Adelmant, Guillaume, Varca, Anthony C., Hu, Bin, Bratt, Ariana S., DaSilva, Ethan, Schauer, Nathan J., Jaen Maisonet, Isabella, Dolen, Emma K., Ayala, Anthony X., Marto, Jarrod A., Buhrlage, Sara J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908924/
https://www.ncbi.nlm.nih.gov/pubmed/36754960
http://dx.doi.org/10.1038/s41467-023-36246-0

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