CryoET reveals organelle phenotypes in huntington disease patient iPSC-derived and mouse primary neurons

Huntington’s disease (HD) is caused by an expanded CAG repeat in the huntingtin gene, yielding a Huntingtin protein with an expanded polyglutamine tract. While experiments with patient-derived induced pluripotent stem cells (iPSCs) can help understand disease, defining pathological biomarkers remain...

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Detalles Bibliográficos
Autores principales: Wu, Gong-Her, Smith-Geater, Charlene, Galaz-Montoya, Jesús G., Gu, Yingli, Gupte, Sanket R., Aviner, Ranen, Mitchell, Patrick G., Hsu, Joy, Miramontes, Ricardo, Wang, Keona Q., Geller, Nicolette R., Hou, Cathy, Danita, Cristina, Joubert, Lydia-Marie, Schmid, Michael F., Yeung, Serena, Frydman, Judith, Mobley, William, Wu, Chengbiao, Thompson, Leslie M., Chiu, Wah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908936/
https://www.ncbi.nlm.nih.gov/pubmed/36754966
http://dx.doi.org/10.1038/s41467-023-36096-w

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