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DSS-induced colitis activates the kynurenine pathway in serum and brain by affecting IDO-1 and gut microbiota

Accumulative studies suggest that inflammatory bowel disease (IBD) may cause multiple central nervous system (CNS) pathologies. Studies have found that indoleamine-2,3-dioxygenase (IDO, rate-limiting enzyme of the kynurenine (Kyn) pathway) deficient mice were protected from endotoxin induced cogniti...

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Detalles Bibliográficos
Autores principales:	Zhao, Li-Ping, Wu, Jian, Quan, Wei, Zhou, Yu, Hong, Hui, Niu, Gu-Yu, Li, Ting, Huang, Shu-Bing, Qiao, Chen-Meng, Zhao, Wei-Jiang, Cui, Chun, Shen, Yan-Qin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908955/ https://www.ncbi.nlm.nih.gov/pubmed/36776388 http://dx.doi.org/10.3389/fimmu.2022.1089200

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