VGLL3 is a mechanosensitive protein that promotes cardiac fibrosis through liquid–liquid phase separation

Myofibroblasts cause tissue fibrosis by producing extracellular matrix proteins, such as collagens. Humoral factors like TGF-β, and matrix stiffness are important for collagen production by myofibroblasts. However, the molecular mechanisms regulating their ability to produce collagen remain poorly c...

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Detalles Bibliográficos
Autores principales: Horii, Yuma, Matsuda, Shoichi, Toyota, Chikashi, Morinaga, Takumi, Nakaya, Takeo, Tsuchiya, Soken, Ohmuraya, Masaki, Hironaka, Takanori, Yoshiki, Ryo, Kasai, Kotaro, Yamauchi, Yuto, Takizawa, Noburo, Nagasaka, Akiomi, Tanaka, Akira, Kosako, Hidetaka, Nakaya, Michio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908974/
https://www.ncbi.nlm.nih.gov/pubmed/36754961
http://dx.doi.org/10.1038/s41467-023-36189-6

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