Pyroptosis and degenerative diseases of the elderly

Pyroptosis is a recently described mechanism of programmed cell death mediated by proteins of the gasdermin family. Widely recognized signaling cascades include the classical, non-classical, caspase-3-dependent gasdermin E and caspase-8-dependent gasdermin D pathways. Additional pyroptotic pathways...

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Autores principales: Zhou, Jiamin, Qiu, Jingjing, Song, Yuwan, Liang, Tiantian, Liu, Sha, Ren, Chao, Song, Xicheng, Cui, Limei, Sun, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908978/
https://www.ncbi.nlm.nih.gov/pubmed/36755014
http://dx.doi.org/10.1038/s41419-023-05634-1
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author Zhou, Jiamin
Qiu, Jingjing
Song, Yuwan
Liang, Tiantian
Liu, Sha
Ren, Chao
Song, Xicheng
Cui, Limei
Sun, Yan
author_facet Zhou, Jiamin
Qiu, Jingjing
Song, Yuwan
Liang, Tiantian
Liu, Sha
Ren, Chao
Song, Xicheng
Cui, Limei
Sun, Yan
author_sort Zhou, Jiamin
collection PubMed
description Pyroptosis is a recently described mechanism of programmed cell death mediated by proteins of the gasdermin family. Widely recognized signaling cascades include the classical, non-classical, caspase-3-dependent gasdermin E and caspase-8-dependent gasdermin D pathways. Additional pyroptotic pathways have been subsequently reported. With the rising prevalence of advanced age, the role of pyroptosis in the degenerative diseases of the elderly has attracted increased research attention. This article reviews the primary mechanisms of pyroptosis and summarizes progress in the research of degenerative diseases of the elderly such as presbycusis, age-related macular degeneration, Alzheimer’s disease, intervertebral disc degeneration, and osteoarthritis.
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spelling pubmed-99089782023-02-10 Pyroptosis and degenerative diseases of the elderly Zhou, Jiamin Qiu, Jingjing Song, Yuwan Liang, Tiantian Liu, Sha Ren, Chao Song, Xicheng Cui, Limei Sun, Yan Cell Death Dis Review Article Pyroptosis is a recently described mechanism of programmed cell death mediated by proteins of the gasdermin family. Widely recognized signaling cascades include the classical, non-classical, caspase-3-dependent gasdermin E and caspase-8-dependent gasdermin D pathways. Additional pyroptotic pathways have been subsequently reported. With the rising prevalence of advanced age, the role of pyroptosis in the degenerative diseases of the elderly has attracted increased research attention. This article reviews the primary mechanisms of pyroptosis and summarizes progress in the research of degenerative diseases of the elderly such as presbycusis, age-related macular degeneration, Alzheimer’s disease, intervertebral disc degeneration, and osteoarthritis. Nature Publishing Group UK 2023-02-09 /pmc/articles/PMC9908978/ /pubmed/36755014 http://dx.doi.org/10.1038/s41419-023-05634-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Zhou, Jiamin
Qiu, Jingjing
Song, Yuwan
Liang, Tiantian
Liu, Sha
Ren, Chao
Song, Xicheng
Cui, Limei
Sun, Yan
Pyroptosis and degenerative diseases of the elderly
title Pyroptosis and degenerative diseases of the elderly
title_full Pyroptosis and degenerative diseases of the elderly
title_fullStr Pyroptosis and degenerative diseases of the elderly
title_full_unstemmed Pyroptosis and degenerative diseases of the elderly
title_short Pyroptosis and degenerative diseases of the elderly
title_sort pyroptosis and degenerative diseases of the elderly
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908978/
https://www.ncbi.nlm.nih.gov/pubmed/36755014
http://dx.doi.org/10.1038/s41419-023-05634-1
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