Analyzing the diffusion and duration of antibodies to SARS-CoV-2 during the natural infection and comparison with vaccination

To monitor SARS-CoV-2 diffusion, we measured anti-Spike S1/S2 IgGs in the serum of nearly 4000 workers employed in several healthcare facilities for one year. We found that the antibody response persists at least over 8 months in symptomatic subjects, particularly in individuals with anosmia/dysgeus...

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Detalles Bibliográficos
Autores principales: Pozzi, Chiara, Azzolini, Elena, Rescigno, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909149/
https://www.ncbi.nlm.nih.gov/pubmed/36785809
http://dx.doi.org/10.1140/epjp/s13360-023-03732-9
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author Pozzi, Chiara
Azzolini, Elena
Rescigno, Maria
author_facet Pozzi, Chiara
Azzolini, Elena
Rescigno, Maria
author_sort Pozzi, Chiara
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description To monitor SARS-CoV-2 diffusion, we measured anti-Spike S1/S2 IgGs in the serum of nearly 4000 workers employed in several healthcare facilities for one year. We found that the antibody response persists at least over 8 months in symptomatic subjects, particularly in individuals with anosmia/dysgeusia. Moreover, analyzing a smaller cohort (124 healthcare employees of which 57 had a previous history of SARS-CoV-2 exposure) vaccinated with two doses of Comirnaty vaccine, we observed that in symptomatic subjects previously exposed to SARS-CoV-2 one dose vaccine was sufficient to stimulate very high levels of antibodies, suggesting that these subjects should take only one dose of vaccine.
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spelling pubmed-99091492023-02-09 Analyzing the diffusion and duration of antibodies to SARS-CoV-2 during the natural infection and comparison with vaccination Pozzi, Chiara Azzolini, Elena Rescigno, Maria Eur Phys J Plus Regular Article To monitor SARS-CoV-2 diffusion, we measured anti-Spike S1/S2 IgGs in the serum of nearly 4000 workers employed in several healthcare facilities for one year. We found that the antibody response persists at least over 8 months in symptomatic subjects, particularly in individuals with anosmia/dysgeusia. Moreover, analyzing a smaller cohort (124 healthcare employees of which 57 had a previous history of SARS-CoV-2 exposure) vaccinated with two doses of Comirnaty vaccine, we observed that in symptomatic subjects previously exposed to SARS-CoV-2 one dose vaccine was sufficient to stimulate very high levels of antibodies, suggesting that these subjects should take only one dose of vaccine. Springer Berlin Heidelberg 2023-02-09 2023 /pmc/articles/PMC9909149/ /pubmed/36785809 http://dx.doi.org/10.1140/epjp/s13360-023-03732-9 Text en © The Author(s), under exclusive licence to Società Italiana di Fisica and Springer-Verlag GmbH Germany, part of Springer Nature 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Regular Article
Pozzi, Chiara
Azzolini, Elena
Rescigno, Maria
Analyzing the diffusion and duration of antibodies to SARS-CoV-2 during the natural infection and comparison with vaccination
title Analyzing the diffusion and duration of antibodies to SARS-CoV-2 during the natural infection and comparison with vaccination
title_full Analyzing the diffusion and duration of antibodies to SARS-CoV-2 during the natural infection and comparison with vaccination
title_fullStr Analyzing the diffusion and duration of antibodies to SARS-CoV-2 during the natural infection and comparison with vaccination
title_full_unstemmed Analyzing the diffusion and duration of antibodies to SARS-CoV-2 during the natural infection and comparison with vaccination
title_short Analyzing the diffusion and duration of antibodies to SARS-CoV-2 during the natural infection and comparison with vaccination
title_sort analyzing the diffusion and duration of antibodies to sars-cov-2 during the natural infection and comparison with vaccination
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909149/
https://www.ncbi.nlm.nih.gov/pubmed/36785809
http://dx.doi.org/10.1140/epjp/s13360-023-03732-9
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