Large Common Mitochondrial DNA Deletions Are Associated with a Mitochondrial SNP T14798C Near the 3′ Breakpoints

INTRODUCTION: Large somatic deletions of mitochondrial DNA (mtDNA) accumulate with aging in metabolically active tissues such as the brain. We have cataloged the breakpoints and frequencies of large mtDNA deletions in the human brain. METHODS: We quantified 112 high-frequency mtDNA somatic deletions...

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Detalles Bibliográficos
Autores principales: Hjelm, Brooke E., Ramiro, Christian, Rollins, Brandi L., Omidsalar, Audrey A., Gerke, Daniel S., Das, Sujan C., Sequeira, Adolfo, Morgan, Ling, Schatzberg, Alan F., Barchas, Jack D., Lee, Francis S., Myers, Richard M., Watson, Stanley J., Akil, Huda, Bunney, William E., Vawter, Marquis P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909249/
https://www.ncbi.nlm.nih.gov/pubmed/36778651
http://dx.doi.org/10.1159/000528051

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