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Inhibition of specific signaling pathways rather than epigenetic silencing of effector genes is the leading mechanism of innate tolerance

INTRODUCTION: Macrophages activated through a pattern-recognition receptor (PRR) enter a transient state of tolerance characterized by diminished responsiveness to restimulation of the same receptor. Signaling-based and epigenetic mechanisms are invoked to explain this innate tolerance. However, the...

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Detalles Bibliográficos
Autores principales:	Masyutina, Anna M., Maximchik, Polina V., Chkadua, Georgy Z., Pashenkov, Mikhail V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909295/ https://www.ncbi.nlm.nih.gov/pubmed/36776861 http://dx.doi.org/10.3389/fimmu.2023.1006002

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