Cargando…

Crystal structure of the phosphorylated Arabidopsis MKK5 reveals activation mechanism of MAPK kinases : Activation mechanism of AtMKK5

The mitogen-activated protein kinase (MAPK) signaling pathways are highly conserved in eukaryotes, regulating various cellular processes. The MAPK kinases (MKKs) are dual specificity kinases, serving as convergence and divergence points of the tripartite MAPK cascades. Here, we investigate the bioch...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pei, Chao-Jun, He, Qing-Xia, Luo, Zhipu, Yao, Hongwei, Wang, Zhi-Xin, Wu, Jia-Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909325/ https://www.ncbi.nlm.nih.gov/pubmed/35866601 http://dx.doi.org/10.3724/abbs.2022089

Ejemplares similares

Knockout of AtMKK1 enhances salt tolerance and modifies metabolic activities in Arabidopsis
por: Conroy, Chad, et al.
Publicado: (2013)

Differential Roles of MAPK Kinases MKK3 and MKK6 in Osteoclastogenesis and Bone Loss
por: Boyle, David L., et al.
Publicado: (2014)

Correction: Differential Roles of MAPK Kinases MKK3 and MKK6 in Osteoclastogenesis and Bone Loss
por: Boyle, David L., et al.
Publicado: (2014)

Molecular mechanism by which Apis cerana cerana MKK6 (AccMKK6)-mediated MAPK cascades regulate the oxidative stress response
por: Wang, Xinxin, et al.
Publicado: (2018)

Balance between MKK6 and MKK3 Mediates p38 MAPK Associated Resistance to Cisplatin in NSCLC
por: Galan-Moya, Eva M., et al.
Publicado: (2011)

Assessing developmental roles of MKK4 and MKK7 in vitro
por: Wang, Jingcai, et al.
Publicado: (2012)

MKK3 Was Involved in Larval Settlement of the Barnacle Amphibalanus amphitrite through Activating the Kinase Activity of p38MAPK
por: Zhang, Gen, et al.
Publicado: (2013)

EDR1 Physically Interacts with MKK4/MKK5 and Negatively Regulates a MAP Kinase Cascade to Modulate Plant Innate Immunity
por: Zhao, Chunzhao, et al.
Publicado: (2014)

Insights of Crosstalk between p53 Protein and the MKK3/MKK6/p38 MAPK Signaling Pathway in Cancer
por: Stramucci, Lorenzo, et al.
Publicado: (2018)

MKK3 as oncotarget
por: Bossi, Gianluca
Publicado: (2016)

TLR and TNF-R1 activation of the MKK3/MKK6–p38α axis in macrophages is mediated by TPL-2 kinase
por: Pattison, Michael J., et al.
Publicado: (2016)

Combined (15)N-Labeling and TandemMOAC Quantifies Phosphorylation of MAP Kinase Substrates Downstream of MKK7 in Arabidopsis
por: Huck, Nicola V., et al.
Publicado: (2017)

Mitogen-activated protein kinase kinase 5 (MKK5)-mediated signalling cascade regulates expression of iron superoxide dismutase gene in Arabidopsis under salinity stress
por: Xing, Yu, et al.
Publicado: (2015)

A Non-Redundant Role for Drosophila Mkk4 and Hemipterous/Mkk7 in TAK1-Mediated Activation of JNK
por: Geuking, Peter, et al.
Publicado: (2009)

The MKK7-MPK6 MAP Kinase Module Is a Regulator of Meristem Quiescence or Active Growth in Arabidopsis
por: Dóczi, Róbert, et al.
Publicado: (2019)

Corrigendum to: Mitogen-activated protein kinase kinase 5 (MKK5)-mediated signaling cascade regulates expression of iron superoxide dismutase gene in Arabidopsis under salinity stress
por: Xing, Yu, et al.
Publicado: (2021)

HINKEL kinesin, ANP MAPKKKs and MKK6/ANQ MAPKK, which phosphorylates and activates MPK4 MAPK, constitute a pathway that is required for cytokinesis in Arabidopsis thaliana
por: Takahashi, Yuji, et al.
Publicado: (2010)

Tomato SlMKK2 and SlMKK4 contribute to disease resistance against Botrytis cinerea
por: Li, Xiaohui, et al.
Publicado: (2014)

A Protoberberine Derivative HWY336 Selectively Inhibits MKK4 and MKK7 in Mammalian Cells: The Importance of Activation Loop on Selectivity
por: Kim, Namil, et al.
Publicado: (2014)

Integration analysis of MKK and MAPK family members highlights potential MAPK signaling modules in cotton
por: Zhang, Xueying, et al.
Publicado: (2016)

Neuroprotection by MKK7 inhibition in excitotoxicity
por: Vercelli, Alessandro, et al.
Publicado: (2015)

Mkk4 and Mkk7 are important for retinal development and axonal injury-induced retinal ganglion cell death
por: Syc-Mazurek, Stephanie B., et al.
Publicado: (2018)

Mitogen-Activated Protein Kinase Cascade MKK7-MPK6 Plays Important Roles in Plant Development and Regulates Shoot Branching by Phosphorylating PIN1 in Arabidopsis
por: Jia, Weiyan, et al.
Publicado: (2016)

MKK3 sustains cell proliferation and survival through p38DELTA MAPK activation in colorectal cancer
por: Stramucci, Lorenzo, et al.
Publicado: (2019)

Dual Mkk4 and Mkk7 Gene Deletion in Adult Mouse Causes an Impairment of Hippocampal Immature Granule Cells
por: Castro-Torres, Rubén Darío, et al.
Publicado: (2021)

Inflammatory mechanisms in post-traumatic osteoarthritis: a role for CaMKK2
por: Riggs, Keegan C., et al.
Publicado: (2023)

MKK4/5-MPK3/6 Cascade Regulates Agrobacterium-Mediated Transformation by Modulating Plant Immunity in Arabidopsis
por: Liu, Tengfei, et al.
Publicado: (2021)

The MAPK kinase BcMkk1 suppresses oxalic acid biosynthesis via impeding phosphorylation of BcRim15 by BcSch9 in Botrytis cinerea
por: Yin, Yanni, et al.
Publicado: (2018)

Activation of AMPK by Bitter Melon Triterpenoids Involves CaMKKβ
por: Iseli, Tristan J., et al.
Publicado: (2013)

Diverse Roles of JNK and MKK Pathways in the Brain
por: Yamasaki, Tokiwa, et al.
Publicado: (2012)

Mitogen Kinase Kinase (MKK7) Controls Cytokine Production In Vitro and In Vivo in Mice
por: Caliz, Amada D., et al.
Publicado: (2021)

Downregulation of phosphorylated MKK4 is associated with a poor prognosis in colorectal cancer patients
por: Wang, Pu-Ning, et al.
Publicado: (2017)

Fas Induces Cytoplasmic Apoptotic Responses and Activation of the MKK7-JNK/SAPK and MKK6-p38 Pathways Independent of CPP32-like Proteases
por: Toyoshima, Fumiko, et al.
Publicado: (1997)

Author Correction: Mkk4 and Mkk7 are important for retinal development and axonal injury-induced retinal ganglion cell death
por: Syc-Mazurek, Stephanie B., et al.
Publicado: (2019)

MKK6 deficiency promotes cardiac dysfunction through MKK3-p38γ/δ-mTOR hyperactivation
por: Romero-Becerra, Rafael, et al.
Publicado: (2022)

Arabidopsis MKK10-MPK6 mediates red-light-regulated opening of seedling cotyledons through phosphorylation of PIF3
por: Xin, Xiaoyun, et al.
Publicado: (2018)

The MKKK62-MKK3-MAPK7/14 module negatively regulates seed dormancy in rice
por: Mao, Xingxue, et al.
Publicado: (2019)

The MKK2a Gene Involved in the MAPK Signaling Cascades Enhances Populus Salt Tolerance
por: Wang, Jiali, et al.
Publicado: (2022)

Targeting MKK3 as a novel anticancer strategy: molecular mechanisms and therapeutical implications
por: Baldari, S, et al.
Publicado: (2015)

CaMKKβ Is Involved in AMP-Activated Protein Kinase Activation by Baicalin in LKB1 Deficient Cell Lines
por: Ma, Ying, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_g5lavdffq8mgodrjobt7h8kod6