Regulation of mRNA stability contributes to the function of innate lymphoid cells in various diseases

Innate lymphoid cells (ILCs) are important subsets of innate immune cells that regulate mucosal immunity. ILCs include natural killer cells, innate lymphoid cells-1 (ILC1s), ILC2s, and ILC3s, which have extremely important roles in the immune system. In this review, we summarize the regulation of mR...

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Detalles Bibliográficos
Autores principales: Deng, Yuanyu, Shi, Saiyu, Luo, Jie, Zhang, Yiwei, Dong, Hui, Wang, Xian, Zhou, Jian, Wei, Zhiyuan, Li, Jiahui, Xu, Chen, Xu, Shuai, Sun, Yi, Ni, Bing, Wu, Yuzhang, Yang, Di, Han, Chao, Tian, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909350/
https://www.ncbi.nlm.nih.gov/pubmed/36776864
http://dx.doi.org/10.3389/fimmu.2023.1118483
Descripción
Sumario:Innate lymphoid cells (ILCs) are important subsets of innate immune cells that regulate mucosal immunity. ILCs include natural killer cells, innate lymphoid cells-1 (ILC1s), ILC2s, and ILC3s, which have extremely important roles in the immune system. In this review, we summarize the regulation of mRNA stability mediated through various factors in ILCs (e.g., cytokines, RNA-binding proteins, non-coding RNAs) and their roles in mediating functions in different ILC subsets. In addition, we discuss potential therapeutic targets for diseases such as chronic obstructive pulmonary disease, cancer, and pulmonary fibrosis by regulation of mRNA stability in ILCs, which may provide novel directions for future clinical research.

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