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Delayed Oxaliplatin-Related Severe Neurotoxicity in Metastatic Colorectal Cancer: A Case Report

In patients receiving oxaliplatin-based chemotherapy, resulting in frequent peripheral neuropathy and requiring long-term management, anticancer drug-induced platinum-based peripheral neuropathy (mixed motor, sensory, and autonomic neuropathy) can result in the coasting phenomenon in which the sympt...

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Autores principales: Iimura, Yohei, Furukawa, Naoki, Kuroda, Seiichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909361/
https://www.ncbi.nlm.nih.gov/pubmed/36779106
http://dx.doi.org/10.7759/cureus.33578
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author Iimura, Yohei
Furukawa, Naoki
Kuroda, Seiichiro
author_facet Iimura, Yohei
Furukawa, Naoki
Kuroda, Seiichiro
author_sort Iimura, Yohei
collection PubMed
description In patients receiving oxaliplatin-based chemotherapy, resulting in frequent peripheral neuropathy and requiring long-term management, anticancer drug-induced platinum-based peripheral neuropathy (mixed motor, sensory, and autonomic neuropathy) can result in the coasting phenomenon in which the symptoms worsen temporarily after two to three weeks, even after the cessation of the drug. The coasting phenomenon is difficult to manage due to the unpredictable nature of the symptoms. We encountered a patient with grade 3 peripheral neuropathy that developed rapidly in the second cycle after the treatment to switch from mFOLFOX6/bevacizumab to FOLFIRI/aflibercept. Supportive care with duloxetine was unsuccessful in this patient. Herein, we report the case.
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spelling pubmed-99093612023-02-10 Delayed Oxaliplatin-Related Severe Neurotoxicity in Metastatic Colorectal Cancer: A Case Report Iimura, Yohei Furukawa, Naoki Kuroda, Seiichiro Cureus Neurology In patients receiving oxaliplatin-based chemotherapy, resulting in frequent peripheral neuropathy and requiring long-term management, anticancer drug-induced platinum-based peripheral neuropathy (mixed motor, sensory, and autonomic neuropathy) can result in the coasting phenomenon in which the symptoms worsen temporarily after two to three weeks, even after the cessation of the drug. The coasting phenomenon is difficult to manage due to the unpredictable nature of the symptoms. We encountered a patient with grade 3 peripheral neuropathy that developed rapidly in the second cycle after the treatment to switch from mFOLFOX6/bevacizumab to FOLFIRI/aflibercept. Supportive care with duloxetine was unsuccessful in this patient. Herein, we report the case. Cureus 2023-01-10 /pmc/articles/PMC9909361/ /pubmed/36779106 http://dx.doi.org/10.7759/cureus.33578 Text en Copyright © 2023, Iimura et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Neurology
Iimura, Yohei
Furukawa, Naoki
Kuroda, Seiichiro
Delayed Oxaliplatin-Related Severe Neurotoxicity in Metastatic Colorectal Cancer: A Case Report
title Delayed Oxaliplatin-Related Severe Neurotoxicity in Metastatic Colorectal Cancer: A Case Report
title_full Delayed Oxaliplatin-Related Severe Neurotoxicity in Metastatic Colorectal Cancer: A Case Report
title_fullStr Delayed Oxaliplatin-Related Severe Neurotoxicity in Metastatic Colorectal Cancer: A Case Report
title_full_unstemmed Delayed Oxaliplatin-Related Severe Neurotoxicity in Metastatic Colorectal Cancer: A Case Report
title_short Delayed Oxaliplatin-Related Severe Neurotoxicity in Metastatic Colorectal Cancer: A Case Report
title_sort delayed oxaliplatin-related severe neurotoxicity in metastatic colorectal cancer: a case report
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909361/
https://www.ncbi.nlm.nih.gov/pubmed/36779106
http://dx.doi.org/10.7759/cureus.33578
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