Cargando…
Safety evaluation of the food enzyme d‐tagatose 3‐epimerase from the genetically modified Escherichia coli strain PS‐Sav‐001
The food enzyme d‐tagatose 3‐epimerase (EC 5.1.3.31) is produced with the genetically modified Escherichia coli strain PS‐Sav‐001 by SAVANNA Ingredients GmbH. The genetic modifications do not give rise to safety concerns. The food enzyme is considered free from viable cells of the production organis...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909378/ https://www.ncbi.nlm.nih.gov/pubmed/36789357 http://dx.doi.org/10.2903/j.efsa.2023.7752 |
_version_ | 1784884562909724672 |
---|---|
author | Lambré, Claude Barat Baviera, José Manuel Bolognesi, Claudia Cocconcelli, Pier Sandro Crebelli, Riccardo Gott, David Michael Grob, Konrad Lampi, Evgenia Mengelers, Marcel Mortensen, Alicja Rivière, Gilles Steffensen, Inger‐Lise Tlustos, Christina Van Loveren, Henk Vernis, Laurence Zorn, Holger Glandorf, Boet Herman, Lieve Andryszkiewicz, Magdalena Gomes, Ana Liu, Yi Peluso, Silvia Chesson, Andrew |
author_facet | Lambré, Claude Barat Baviera, José Manuel Bolognesi, Claudia Cocconcelli, Pier Sandro Crebelli, Riccardo Gott, David Michael Grob, Konrad Lampi, Evgenia Mengelers, Marcel Mortensen, Alicja Rivière, Gilles Steffensen, Inger‐Lise Tlustos, Christina Van Loveren, Henk Vernis, Laurence Zorn, Holger Glandorf, Boet Herman, Lieve Andryszkiewicz, Magdalena Gomes, Ana Liu, Yi Peluso, Silvia Chesson, Andrew |
collection | PubMed |
description | The food enzyme d‐tagatose 3‐epimerase (EC 5.1.3.31) is produced with the genetically modified Escherichia coli strain PS‐Sav‐001 by SAVANNA Ingredients GmbH. The genetic modifications do not give rise to safety concerns. The food enzyme is considered free from viable cells of the production organism and its DNA. The food enzyme is used while retained inside a membrane reactor to convert d‐fructose into the speciality carbohydrate d‐allulose (syn. d‐psicose). Since residual amounts of total organic solids (TOS) are removed by the purification steps applied during the production of d‐allulose, dietary exposure was not calculated and toxicological studies were not considered necessary. A search for the similarity of the amino acid sequence of the food enzyme to known allergens was made and no match was found. The Panel considered that under the intended conditions of use, the risk of allergic reactions by dietary exposure cannot be excluded, but the likelihood is low. Based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use. |
format | Online Article Text |
id | pubmed-9909378 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99093782023-02-13 Safety evaluation of the food enzyme d‐tagatose 3‐epimerase from the genetically modified Escherichia coli strain PS‐Sav‐001 Lambré, Claude Barat Baviera, José Manuel Bolognesi, Claudia Cocconcelli, Pier Sandro Crebelli, Riccardo Gott, David Michael Grob, Konrad Lampi, Evgenia Mengelers, Marcel Mortensen, Alicja Rivière, Gilles Steffensen, Inger‐Lise Tlustos, Christina Van Loveren, Henk Vernis, Laurence Zorn, Holger Glandorf, Boet Herman, Lieve Andryszkiewicz, Magdalena Gomes, Ana Liu, Yi Peluso, Silvia Chesson, Andrew EFSA J Scientific Opinion The food enzyme d‐tagatose 3‐epimerase (EC 5.1.3.31) is produced with the genetically modified Escherichia coli strain PS‐Sav‐001 by SAVANNA Ingredients GmbH. The genetic modifications do not give rise to safety concerns. The food enzyme is considered free from viable cells of the production organism and its DNA. The food enzyme is used while retained inside a membrane reactor to convert d‐fructose into the speciality carbohydrate d‐allulose (syn. d‐psicose). Since residual amounts of total organic solids (TOS) are removed by the purification steps applied during the production of d‐allulose, dietary exposure was not calculated and toxicological studies were not considered necessary. A search for the similarity of the amino acid sequence of the food enzyme to known allergens was made and no match was found. The Panel considered that under the intended conditions of use, the risk of allergic reactions by dietary exposure cannot be excluded, but the likelihood is low. Based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use. John Wiley and Sons Inc. 2023-02-09 /pmc/articles/PMC9909378/ /pubmed/36789357 http://dx.doi.org/10.2903/j.efsa.2023.7752 Text en © 2023 European Food Safety Authority. EFSA Journal published by Wiley‐VCH GmbH on behalf of European Food Safety Authority. https://creativecommons.org/licenses/by-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ (https://creativecommons.org/licenses/by-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made. |
spellingShingle | Scientific Opinion Lambré, Claude Barat Baviera, José Manuel Bolognesi, Claudia Cocconcelli, Pier Sandro Crebelli, Riccardo Gott, David Michael Grob, Konrad Lampi, Evgenia Mengelers, Marcel Mortensen, Alicja Rivière, Gilles Steffensen, Inger‐Lise Tlustos, Christina Van Loveren, Henk Vernis, Laurence Zorn, Holger Glandorf, Boet Herman, Lieve Andryszkiewicz, Magdalena Gomes, Ana Liu, Yi Peluso, Silvia Chesson, Andrew Safety evaluation of the food enzyme d‐tagatose 3‐epimerase from the genetically modified Escherichia coli strain PS‐Sav‐001 |
title | Safety evaluation of the food enzyme d‐tagatose 3‐epimerase from the genetically modified Escherichia coli strain PS‐Sav‐001
|
title_full | Safety evaluation of the food enzyme d‐tagatose 3‐epimerase from the genetically modified Escherichia coli strain PS‐Sav‐001
|
title_fullStr | Safety evaluation of the food enzyme d‐tagatose 3‐epimerase from the genetically modified Escherichia coli strain PS‐Sav‐001
|
title_full_unstemmed | Safety evaluation of the food enzyme d‐tagatose 3‐epimerase from the genetically modified Escherichia coli strain PS‐Sav‐001
|
title_short | Safety evaluation of the food enzyme d‐tagatose 3‐epimerase from the genetically modified Escherichia coli strain PS‐Sav‐001
|
title_sort | safety evaluation of the food enzyme d‐tagatose 3‐epimerase from the genetically modified escherichia coli strain ps‐sav‐001 |
topic | Scientific Opinion |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909378/ https://www.ncbi.nlm.nih.gov/pubmed/36789357 http://dx.doi.org/10.2903/j.efsa.2023.7752 |
work_keys_str_mv | AT safetyevaluationofthefoodenzymedtagatose3epimerasefromthegeneticallymodifiedescherichiacolistrainpssav001 AT lambreclaude safetyevaluationofthefoodenzymedtagatose3epimerasefromthegeneticallymodifiedescherichiacolistrainpssav001 AT baratbavierajosemanuel safetyevaluationofthefoodenzymedtagatose3epimerasefromthegeneticallymodifiedescherichiacolistrainpssav001 AT bolognesiclaudia safetyevaluationofthefoodenzymedtagatose3epimerasefromthegeneticallymodifiedescherichiacolistrainpssav001 AT cocconcellipiersandro safetyevaluationofthefoodenzymedtagatose3epimerasefromthegeneticallymodifiedescherichiacolistrainpssav001 AT crebelliriccardo safetyevaluationofthefoodenzymedtagatose3epimerasefromthegeneticallymodifiedescherichiacolistrainpssav001 AT gottdavidmichael safetyevaluationofthefoodenzymedtagatose3epimerasefromthegeneticallymodifiedescherichiacolistrainpssav001 AT grobkonrad safetyevaluationofthefoodenzymedtagatose3epimerasefromthegeneticallymodifiedescherichiacolistrainpssav001 AT lampievgenia safetyevaluationofthefoodenzymedtagatose3epimerasefromthegeneticallymodifiedescherichiacolistrainpssav001 AT mengelersmarcel safetyevaluationofthefoodenzymedtagatose3epimerasefromthegeneticallymodifiedescherichiacolistrainpssav001 AT mortensenalicja safetyevaluationofthefoodenzymedtagatose3epimerasefromthegeneticallymodifiedescherichiacolistrainpssav001 AT rivieregilles safetyevaluationofthefoodenzymedtagatose3epimerasefromthegeneticallymodifiedescherichiacolistrainpssav001 AT steffenseningerlise safetyevaluationofthefoodenzymedtagatose3epimerasefromthegeneticallymodifiedescherichiacolistrainpssav001 AT tlustoschristina safetyevaluationofthefoodenzymedtagatose3epimerasefromthegeneticallymodifiedescherichiacolistrainpssav001 AT vanloverenhenk safetyevaluationofthefoodenzymedtagatose3epimerasefromthegeneticallymodifiedescherichiacolistrainpssav001 AT vernislaurence safetyevaluationofthefoodenzymedtagatose3epimerasefromthegeneticallymodifiedescherichiacolistrainpssav001 AT zornholger safetyevaluationofthefoodenzymedtagatose3epimerasefromthegeneticallymodifiedescherichiacolistrainpssav001 AT glandorfboet safetyevaluationofthefoodenzymedtagatose3epimerasefromthegeneticallymodifiedescherichiacolistrainpssav001 AT hermanlieve safetyevaluationofthefoodenzymedtagatose3epimerasefromthegeneticallymodifiedescherichiacolistrainpssav001 AT andryszkiewiczmagdalena safetyevaluationofthefoodenzymedtagatose3epimerasefromthegeneticallymodifiedescherichiacolistrainpssav001 AT gomesana safetyevaluationofthefoodenzymedtagatose3epimerasefromthegeneticallymodifiedescherichiacolistrainpssav001 AT liuyi safetyevaluationofthefoodenzymedtagatose3epimerasefromthegeneticallymodifiedescherichiacolistrainpssav001 AT pelusosilvia safetyevaluationofthefoodenzymedtagatose3epimerasefromthegeneticallymodifiedescherichiacolistrainpssav001 AT chessonandrew safetyevaluationofthefoodenzymedtagatose3epimerasefromthegeneticallymodifiedescherichiacolistrainpssav001 |