ICOS costimulation is indispensable for the differentiation of T follicular regulatory cells

ICOS is a T-cell costimulatory receptor critical for Tfh cell generation and function. However, the role of ICOS in Tfr cell differentiation remains unclear. Using Foxp3-Cre–mediated ICOS knockout (ICOS FC) mice, we show that ICOS deficiency in Treg-lineage cells drastically reduces the number of Tf...

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Detalles Bibliográficos
Autores principales: Panneton, Vincent, Mindt, Barbara C, Bouklouch, Yasser, Bouchard, Antoine, Mohammaei, Saba, Chang, Jinsam, Diamantopoulos, Nikoletta, Witalis, Mariko, Li, Joanna, Stancescu, Albert, Bradley, John E, Randall, Troy D, Fritz, Jörg H, Suh, Woong-Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909462/
https://www.ncbi.nlm.nih.gov/pubmed/36754569
http://dx.doi.org/10.26508/lsa.202201615

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