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Greater alteration of gut microbiota occurs in childhood obesity than in adulthood obesity
The children's gut microbiota, associated with the development of obesity, is in maturation. The impact of obesity on the gut microbiota in childhood could have a more significant effect than on adulthood and eventually be lifelong lasting, but it has been rarely studied. Aimed to discover the...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909466/ https://www.ncbi.nlm.nih.gov/pubmed/36776907 http://dx.doi.org/10.3389/fped.2023.1087401 |
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author | Yu, Zhongjia Yu, Xiang-Fang Zhao, Xiu Su, Zhe Ren, Pei-Gen |
author_facet | Yu, Zhongjia Yu, Xiang-Fang Zhao, Xiu Su, Zhe Ren, Pei-Gen |
author_sort | Yu, Zhongjia |
collection | PubMed |
description | The children's gut microbiota, associated with the development of obesity, is in maturation. The impact of obesity on the gut microbiota in childhood could have a more significant effect than on adulthood and eventually be lifelong lasting, but it has been rarely studied. Aimed to discover the difference in gut microbiota between children and adults with obesity, we collected published amplicon sequencing data from National Center for Biotechnology Information (NCBI) and re-analyzed them using a uniform bioinformatic pipeline, as well as predicted the obesity using gut microbiota based on the random forest model. Summarizing common points among these cohorts, we found that the gut microbiota had a significant difference between children with and without obesity, but this difference was not observed in adult cohorts. Based on the random forest model, it was more challenging to predict childhood obesity using gut microbiota than adulthood obesity. Our results suggest that gut microbiota in childhood is more easily affected than in adulthood. Early intervention for childhood obesity is essential to improve children's health and lifelong gut microbiota-related health. |
format | Online Article Text |
id | pubmed-9909466 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99094662023-02-10 Greater alteration of gut microbiota occurs in childhood obesity than in adulthood obesity Yu, Zhongjia Yu, Xiang-Fang Zhao, Xiu Su, Zhe Ren, Pei-Gen Front Pediatr Pediatrics The children's gut microbiota, associated with the development of obesity, is in maturation. The impact of obesity on the gut microbiota in childhood could have a more significant effect than on adulthood and eventually be lifelong lasting, but it has been rarely studied. Aimed to discover the difference in gut microbiota between children and adults with obesity, we collected published amplicon sequencing data from National Center for Biotechnology Information (NCBI) and re-analyzed them using a uniform bioinformatic pipeline, as well as predicted the obesity using gut microbiota based on the random forest model. Summarizing common points among these cohorts, we found that the gut microbiota had a significant difference between children with and without obesity, but this difference was not observed in adult cohorts. Based on the random forest model, it was more challenging to predict childhood obesity using gut microbiota than adulthood obesity. Our results suggest that gut microbiota in childhood is more easily affected than in adulthood. Early intervention for childhood obesity is essential to improve children's health and lifelong gut microbiota-related health. Frontiers Media S.A. 2023-01-26 /pmc/articles/PMC9909466/ /pubmed/36776907 http://dx.doi.org/10.3389/fped.2023.1087401 Text en © 2023 Yu, Yu, Zhao, Su and Ren. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics Yu, Zhongjia Yu, Xiang-Fang Zhao, Xiu Su, Zhe Ren, Pei-Gen Greater alteration of gut microbiota occurs in childhood obesity than in adulthood obesity |
title | Greater alteration of gut microbiota occurs in childhood obesity than in adulthood obesity |
title_full | Greater alteration of gut microbiota occurs in childhood obesity than in adulthood obesity |
title_fullStr | Greater alteration of gut microbiota occurs in childhood obesity than in adulthood obesity |
title_full_unstemmed | Greater alteration of gut microbiota occurs in childhood obesity than in adulthood obesity |
title_short | Greater alteration of gut microbiota occurs in childhood obesity than in adulthood obesity |
title_sort | greater alteration of gut microbiota occurs in childhood obesity than in adulthood obesity |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909466/ https://www.ncbi.nlm.nih.gov/pubmed/36776907 http://dx.doi.org/10.3389/fped.2023.1087401 |
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